Sökning: "fold comparison"

Visar resultat 1 - 5 av 115 avhandlingar innehållade orden fold comparison.

  1. 1. Applications of Structural Bioinformatics for the Structural Genomics Era

    Författare :Marian Novotny; Gerard Kleywegt; Geoff Barton; Uppsala universitet; []
    Nyckelord :Bioinformatics; structural bioinformatics; fold comparison; left-handed helix; docking; solvent-accessible surface area; register shift; X-ray crystallography; Bioinformatik;

    Sammanfattning : Structural bioinformatics deals with the analysis, classification and prediction of three-dimensional structures of biomacromolecules. It is becoming increasingly important as the number of structures is growing rapidly. LÄS MER

  3. 2. Carboligation using the aldol reaction : A comparison of stereoselectivity and methods

    Författare :Derar Al-Smadi; Mikael Widersten; Ulf Nilsson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; aldol reaction; cinchonine; FSA enzyme; homologation reactions; phenylacetaldehyde derivatives; samarium diiodide.;

    Sammanfattning : The research summarized in this thesis focuses on synthesizing aldehyde and aldol compounds as substrates and products for the enzyme D-fructose-6-aldolase (FSA). Aldolases are important enzymes for the formation of carbon-carbon bonds in nature. LÄS MER

  4. 3. Reconstruction of vocal fold scarring with mesenchymal stromal cell therapy

    Författare :Srinivasa Rao Nagubothu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Tissue injury/scarring of the vocal folds (VFs) can be caused by various factors including external trauma, cancer treatment or inflammation, leading to damage within the vibrating layers and a decrease in viscoelastic functions. These effects ultimately result in severe voice problems. This condition leads to significant morbidity for patients. LÄS MER

  5. 4. Prediction of zinc-binding sites in proteins and efficient protein structure description and comparison

    Författare :Nanjiang Shu; Sven Hovmöller; Elisabeth Sauer-Eriksson; Alexander Luybartsev; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; zinc-binding; shape strings; protein structures; secondary structures; machine learning; Molecular biology; Molekylärbiologi; Biochemistry; Biokemi; Bioinformatics; Bioinformatik; Structural biology; Strukturbiologi; Biochemistry; biokemi; strukturbiologi; Structural Biology; Molecular Biology; molekylärbiologi;

    Sammanfattning : A large number of proteins require certain metals to stabilize their structures or to function properly. About one third of all proteins in the Protein Data Bank (PDB) contain metals and it is estimated that approximately the same proportion of all proteins are metalloproteins. LÄS MER

  7. 5. AIDS and endemic Kaposi's sarcoma development : comparison by histopathology, virology (HHV8/KSHV) and cytogenetics

    Författare :Pawan Pyakurel; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Kaposi’s sarcoma (KS) is a highly and abnormally vascularized tumor-like lesion with spindle cells (SC) affecting the skin, lymphnodes and viscera which is found in four different clinico-epidemiological forms as Classic KS (CKS), Iatrogenic KS (IKS), Endemic KS (EKS) and AIDS-associated KS (AKS). All KS forms develop from early stages of patch/plaque to late, nodular tumors and are associated with Kaposi's sarcomaassociated herpesvirus or human herpesvirus-8 (KSHV/ HHV-8). LÄS MER