Sökning: "Sandra Andersson"
Visar resultat 1 - 5 av 11 avhandlingar innehållade orden Sandra Andersson.
1. Volcanic Aerosols in the Upper Troposphere and Stratosphere – Aircraft- and Satellite-Based Observations
Sammanfattning : Volcanic eruptions are the largest source of variability in the stratospheric particle concentration as they inject SO2 that is subsequently converted into sulphate particles. No major perturbation of the stratospheric aerosol load has been observed since the large eruption of Pinatubo in 1991, but several moderate eruptions after 2000 have caused deviations from stratospheric background conditions. LÄS MER
2. Formation of the inhibitory KIR repertoire in human natural killer cells
Sammanfattning : Natural killer (NK) cells are lymphocytes of the innate immune system that are able to secrete cytokines and detect virus infected and transformed cells. Contrary to T cells, NK cells recognize targets that lack expression of MHC class I molecules at the cell surface, a phenomenon referred to as “missing self” recognition. LÄS MER
3. Nuclear receptor functions in the central nervous system : clues from knockout mice
Sammanfattning : The nuclear receptor (NR) superfamily is the largest known family of transcription factors in eukaryotes. In the 1980 s when the size of the NR family and the scope of the functions of its members were being discovered, tissue distribution studies revealed that the mRNAs of many of these receptors were expressed in the central nervous system. LÄS MER
4. The many faces of IGF-1R from cell surface to the nucleus
Sammanfattning : The IGF-1R is due to its implication in cancer an intensively studied subject of research. It is well known today that intracellular signals mediated by the IGF-1R play pivotal roles in tumorigenesis and cancer progression. LÄS MER
5. Validation of antibodies for tissue based immunoassays
Sammanfattning : In situ protein detection in human tissues using antibodies reveals the cellular protein localization, and affinity-based proteomic studies can help to discover proteins involved in the development of diseases. However, antibodies often suffer from cross-reactivity, and the lack of positive and negative tissue controls for uncharacterized proteins complicates the mapping of the proteome. LÄS MER
