Sökning: "drug-induced mitochondrial toxicity"

Hittade 3 avhandlingar innehållade orden drug-induced mitochondrial toxicity.

  1. 1. Mitochondrial medicine. New strategies to evaluate drug toxicity and develop pharmacological protection of the cell’s powerhouse

    Författare :Sarah Piel; Klinisk neurofysiologi; []
    Nyckelord :mitochondria; drug-induced mitochondrial toxicity; mitochondrial disease; mitochondrial medicine; drug development; succinate; methylene blue; metformin; acetaminophen; paracetamol; Kolliphor® EL;

    Sammanfattning : Mitochondria produce the majority of the cell’s energy. Any dysfunction in, or interference with mitochondrial function can have severe consequences. And yet, it was only within the last decades that screening for potential mitochondrial toxicity was included as routine toxicity assay during early drug development. LÄS MER

  3. 2. Sperm Membrane Channels, Receptors and Kinematics : Using boar spermatozoa for drug toxicity screening

    Författare :Alejandro Vicente Carrillo; Heriberto Rodríguez-Martínez; Karl-Eric Magnusson; Rudolf Rigler; Vesa Loitto; Stefan Arver; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Plasma membrane; membrane channels; membrane receptors; kinematics; 3Rprinciples; spermatozoa; boar.;

    Sammanfattning : Internal fertilization usually implies that a spermatozoon, with intact attributes for zygote formation, passes all hurdles during its transport through the female genitalia and reaches the oocyte. During this journey, millions to billions of other spermatozoa perish. LÄS MER

  4. 3. Drug and alcohol induced hepatotoxicity

    Författare :Angelica Butura; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Hepatotoxicity; in vitro models; alcoholic liver disease; CYP2E1;

    Sammanfattning : Drug induced hepatotoxicity is the most common reason cited for withdrawal of already approved drugs from the market and accounts for more than 50 percent of cases of acute liver failure in the United States. Ethanol (EtOH) causes a further substantial amount of liver insufficiencies world wide. LÄS MER