Sökning: "diethylstilbestrol"
Hittade 4 avhandlingar innehållade ordet diethylstilbestrol.
1. Analysis of DNA adducts formed by tamoxifen and related antiestrogenic and estrogenic compounds in rats
Sammanfattning : The work presented herein has focused on DNA adduct formation by the non-steroidal antiestrogen tamoxifen and its analogues. Tamoxifen, [(Z)-1-{4-[2-(dimethylamino)-ethoxy]phenyl}-1,2-diphenyl-1-butene], is widely used in the treatment of breast cancer and its recognised side effect is endometrial cancer. LÄS MER
2. Environmental pollutants and the reproductive system in birds : Developmental effects of estrogenic compounds
Sammanfattning : A number of environmental pollutants have been shown to mimick the action of the female sex hormone estrogen and are, therefore, suspected to be responsible for reproductive abnormalities seen in wildlife. Test systems which can be used in hazard and risk assessment of chemicals with estrogenic effects are consequently needed. LÄS MER
3. Zebrafish as a model to study the neuroendocrine system and toxicity of endocrine disruptors
Sammanfattning : Zebrafish is a popular vertebrate model system to study development and perform genetic analysis. It offers numerous advantages such as small size, short generation time, high fecundity, rapid and ex utero development of embryos and optically transparent embryos. LÄS MER
4. Determinants of ligand-induced nuclear receptor activation
Sammanfattning : The nuclear receptors (NRs) constitute a highly conserved superfamily of transcription factors restricted to metazoans. In general, these receptors are regulated by small lipophilic molecules such as steroids, thyroid hormones and retinoids and play an important role in cellular regulation. LÄS MER