Sökning: "genotoxicity"

Visar resultat 1 - 5 av 36 avhandlingar innehållade ordet genotoxicity.

1. 1. Hazard screening of contaminated sites : bioavailable fractions and biological in vitro tools

   Författare :Daniel Ragnvaldsson; Mats Tysklind; Per Leffler; Lars Lövgren; Bengt-Erik Bengtsson; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Hazard screening; bioavailability; metal pollution; in vitro cytotoxicity; water extraction; CCA; arsenic genotoxicity; genotoxicity; Contaminated soil; Environmental chemistry; Miljökemi;

   Sammanfattning : The environmental bioavailability of contaminants, rather than their total concentrations in the soil compartment play a decisive role for the risks associated with contaminated sites. Various soil constituents and abiotic conditions have strong influence on bioavailability, which may vary substantially between different locations. LÄS MER

3. 2. Chemically Induced DNA Damage in Extended-term Cultures of Human Lymphocytes

   Författare :Maria Andersson; Björn Hellman; Leif Busk; Uppsala universitet; []
   Nyckelord :Toxicology; Comet assay; DNA-damaging agents; DNA repair; Extended-term Cultures of Human Lymphocytes; Genotoxicity; Induced DNA damage; In vitro; Mouse Lymphoma Cells; Primary Cell Cultures; Reactive Oxygen Species; Toxikologi;

   Sammanfattning : Generation of DNA damage is regarded to be an important initial event in the development cancer. Consequently, a battery of tests have been developed to detect different types of genotoxic effects in order to be able to predict the potential genotoxicity and mutagenicity of chemicals, including both pharmaceutical drugs and various types of environmental and occupational agents, as well as dietary factors. LÄS MER

4. 3. Evolving the Methodology for Detection of Primary DNA Damage : Development, adaptation and assessment of the single cell gel electrophoresis (comet) assay

   Författare :Erik Bivehed; Björn Hellman; Hanna Karlsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Comet assay; DNA damage; DNA strand breaks; Flash-comet; Genotoxicity; In vitro; Single cell gel electrophoresis; Polymerase assisted DNA damage assay PADDA ; TK6 cells; UCDAS; U937 cells; Toxikologi; Toxicology; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : Deoxyribonucleic acid (DNA) is one of the most important molecules in nature. It is the fundamental carrier of evolutionary information and constitutes the genetic blueprint of all living organisms. Being the sole source of information, it is vital for the cell to transmit the correct genetic information from generation to generation. LÄS MER

5. 4. Semipermeable membrane devices in monitoring of organic pollutants in the aquatic environment

   Författare :Darius Sabaliunas; Biologiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; effect studies; environmental monitoring; organic pollutants; bioconcentration; passive samplers; Semipermeable membrane devices; SPMDs; toxicity; genotoxicity; bioassays; Ecology; Ekologi;

   Sammanfattning : Semipermeable membrane devices (SPMDs) are passive samplers capable of concentrating hydrophobic chemicals from water, sediments, soil and air. They consist of layflat polymeric membrane such as polyethylene containing a thin film of synthetic lipid such as triolein. LÄS MER

7. 5. Change of toxicity during secondary treatment of industrial sludge containing nitroaromatics

   Författare :Lillemor Gustavsson; Magnus Engwall; Anna Schnürer; Ulrika Welander; Mårten Jönsson; Bo Mattiasson; Göran Dave; Örebro universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Anaerobic; aerobic; AhR agonists; CALUX; constructed wetlands; Danio rerio; embryotoxicity; genotoxicity; nitroaromatics; sludge; Environmental engineering; Miljöteknik; Enviromental Science; Miljövetenskap;

   Sammanfattning : Wastewater treatment plants in Sweden are facing a great challenge due to the prohibition of depositing organic waste which gained legal force in January 2005. Biological and commercial available alternatives to disposal are composting and anaerobic digestion. LÄS MER