Sökning: "copy number alterations"
Visar resultat 1 - 5 av 67 avhandlingar innehållade orden copy number alterations.
1. Copy Number Analysis of Cancer
Sammanfattning : By accurately describing cancer genomes, we may link genomic mutations to phenotypic effects and eventually treat cancer patients based on the molecular cause of their disease, rather than generalizing treatment based on cell morphology or tissue of origin.Alteration of DNA copy number is a driving mutational process in the formation and progression of cancer. LÄS MER
2. Ovarian Carcinoma - Early Detection and Prognostication
Sammanfattning : .... LÄS MER
3. Studies of gene fusions and copy number alterations in salivary and adnexal neoplasms
Sammanfattning : Cancer is a genetic disease caused by the accumulation of genetic changes such as mutations and chromosomal rearrangements. An increasing number of genetic studies of both hematological and solid neoplasms have shown that recurrent chromosome translocations often result in fusion oncogenes. LÄS MER
4. Array based genetic profiling of chronic lymphocytic leukemia
Sammanfattning : Although no common genetic defect has been described in chronic lymphocytic leukemia (CLL), recurrent genomic aberrations (i.e. deletions of chromosome 11q, 13q, 17p and trisomy 12) are important for prognostication. Deletion of 13q as single aberration is associated with the best prognosis, whereas del(11q) and del(17p) predict a poor outcome. LÄS MER
5. Genetic Characterization and Identification of Novel Treatment Targets in Anaplastic Thyroid Carcinoma
Sammanfattning : Anaplastic thyroid cancer (ATC) is a rare and highly aggressive thyroid malignancy, usually resistant to conventional therapeutic strategies. The prognosis of ATC is extremely poor with a median survival rate of 6 months. Current treatment therapy includes surgical resection in combination with external radiotherapy and chemotherapy. LÄS MER