Sökning: "coenzyme q"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden coenzyme q.

  1. 1. Metabolism of coenzyme Q & regulation of its biosynthesis

    Författare :Magnus Bentinger; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Lipider;

    Sammanfattning : .... LÄS MER

  3. 2. Structural and functional studies of protein complexes involved in energy metabolism

    Författare :Jens Berndtsson; Martin Ott; Irene Diaz-Moreno; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mitochondria; metabolism; OXPHOS; yeast respiratory supercomplex; cytochrome c; coenzyme Q; pyruvate dehydrogenase complex; Biochemistry; biokemi;

    Sammanfattning : Mitochondria are eukaryotic organelles with a multitude of functions including biosynthesis of molecules and cellular regulation. Most prominently though is their role in energy conversion which culminates with the production of ATP, the universal molecular unit of currency. LÄS MER

  4. 3. Metal homeostasis as critical determinant for cellular fitness

    Författare :Jutta Diessl; Sabrina Büttner; Rajini Rao; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; metal homeostasis; manganese toxicity; coenzyme Q synthesis; mitochondrial respiration; calcineurin signaling; Pmr1; SPCA1; calcium; survival; caloric restriction; Parkinson’s disease models; proteotoxicity; Pep4; cathepsin D; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Metals play a crucial role in cellular biology. Bulk and trace metals such as calcium and manganese regulate a plethora of cellular processes ranging from signaling and oxidative stress to proteostasis and energy metabolism. LÄS MER

  5. 4. Inhibition of the mevalonate pathway in C. elegans: Consequences and implications

    Författare :Parmida Ranji; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mevalonate pathway; C. elegans; atfs-1; mitochondrial unfolded response UPR ;

    Sammanfattning : The mevalonate pathway in human is responsible for the synthesis of cholesterol and other important biomolecules such as coenzyme Q (a component of the electron transport chain in mitochondria), dolichols (important for N-linked glycosylation of proteins) and isoprenoids (important for the membrane association of small GTPases). This thesis concerns novel findings about the effect of statin on the mevalonate pathway using C. LÄS MER

  7. 5. Oxidative stress and mitochondrial function : role of ubiquinol as antioxidant

    Författare :Patrik Andrée; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Over the last three decades it has been established that biquinone (coenzyme Q), in addition to its function as an electron and proton carrier in the respiratory chain, acts in its reduced form (ubiquinol) as an antioxidant. The main theme of this thesis is a study of the antioxidant function of ubiquinol in preparations of beef heart submitochondrial particles, which consist of inverted vesicular fragments of the inner mitochondrial membrane. LÄS MER