Sökning: "cholesterol absorption"

Visar resultat 6 - 10 av 22 avhandlingar innehållade orden cholesterol absorption.

1. 6. Studies on the regulatory roles of cholesterol and bile acids

   Författare :Charlotte Murphy; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cholesterol; cholic acid; bile acids; cholesterol homeostasis; squalene epoxidase; mevalonate kinase; cob I alamin adenotransferase; SREBP; NF-Y;

   Sammanfattning : Cholesterol is essential for normal growth and development in mammals. However, excess cholesterol can be harmful leading to diseases such as atherosclerosis and gallstones. Once formed the ring structure of cholesterol cannot be catabolised by the body and must therefore be converted to other compounds for excretion. LÄS MER

3. 7. Studies of sterol 12alpha-hydroxylase (CYP8B1) : distribution and role for cholesterol homeostasis and gallstone formation

   Författare :Jin Wang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :CYP8B1; CY7P7A1; bile acid; cholesterol homeostasis; gallstone; nuclear receptor; cellular distribution; cholesterol hypersecretion; ABCG5 G8; SREBP2; cholesterol absorption; diabetes mellitus; anti-atherogenesis;

   Sammanfattning : Bile acids are essential physiological molecules which carry out multiple functions such as facilitating the absorption of dietary lipids and regulating the metabolism of cholesterol and bile acids. The formation of bile represents the major route for elimination of excess cholesterol, either by conversion of cholesterol into bile acids or excretion of intact cholesterol in mixed micelles. LÄS MER

4. 8. Role of cholesterol metabolism in hepatic steatosis and glucose tolerance

   Författare :Osman Salih Osman Ahmed; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The liver is the central organ for lipid, lipoprotein and glucose homeostasis, thus hepatic metabolic disturbances can predispose individuals to develop cardiometabolic disorders (CMD) such as atherosclerotic cardiovascular diseases (ASCVD), type 2 diabetes mellitus (T2DM), and nonalcoholic fatty liver disease (NAFLD).The overall aim of this thesis was to expand the knowledge on how genetic and pharmacological interventions on hepatic and intestinal cholesterol metabolism could affect the pathophysiology of CMD. LÄS MER

5. 9. Nutritional Properties of Liquid Oats as Affected by Processing and Storage

   Författare :Huanmei Zhang; Tillämpad biokemi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biotechnology; Antioxidants; Avenanthramides; Biological value; Iron absorption; Fatty acids; Processing; Minerals; Vitamins; Storage; Stability; Nutritional properties; Oats; Beverage; Bioteknik;

   Sammanfattning : The cholesterol-lowering effects of oats have led to an increasing interest in them on the food market. Liquid oats has emerged as a new way of consuming oats and has become a commercial product. LÄS MER

7. 10. Regulation of the hepatic ACAT2 expression and roles of HNF1alhpa and HNF4alpha in cholesterol metabolism

   Författare :Camilla Pramfalk; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :ACAT2; HNF; MODY; NPC1L1; SREBP; cholesterol metabolism;

   Sammanfattning : Acyl-Coenzyme A:cholesterol acyltransferases (ACATs) 1 and 2 are integral membrane proteins located in rough endoplasmatic reticulum that catalyzes the formation of cholesteryl esters (CEs) from cholesterol and long-chain fatty acids. ACAT1 is present in most tissues, whereas ACAT2 is confined to enterocytes and hepatocytes. LÄS MER