Sökning: "arginase"

Visar resultat 1 - 5 av 14 avhandlingar innehållade ordet arginase.

  1. 1. Radical aspects on arthritis : the role of neutrophil generation of nitric oxide and superoxide in inflammatory conditions

    Författare :Jan Cedergren; Thomas Skogh; Tommy Sundqvist; Tony Forslund; Ingrid Lundberg; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neutrophils; reactive oxygen species; arthritis; NOS; NO; arginase; integrins; Internal medicine; Invärtesmedicin;

    Sammanfattning : The polymorphonuclear neutrophil granulocytes (neutrophils) are gaining renewed interest regarding their involvement in chronic inflammatory disorders, including rheumatoid arthritis (RA). Besides phagocytic and destructive capabilities, neutrophils have regulatory roles, e.g. by influencing responses from dendritic cells and lymphocytes. LÄS MER

  3. 2. Role of arginase in vascular function

    Författare :Christian Jung; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Nitric oxide (NO) is central for the integrity of the cardiovascular system, the maintenance of endothelial function and the protection against ischaemic heart disease. The enzyme arginase is up-regulated during ischaemia-reperfusion and by hypoxia in cell culture and animal models which might be of pathophysiological relevance since it competes with NO synthase for their common substrate arginine. LÄS MER

  4. 3. The importance of arginase for vascular dysfunction in patients with glucose and lipid abnormalities

    Författare :Oskar Kövamees; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Introduction: Endothelial dysfunction is one important mediator behind atherosclerosis. Maintained bioavailability of nitric oxide (NO) is critical to keep the fragile balance of endothelial function. Reduced NO arise from reduced production or increased elimination of NO. LÄS MER

  5. 4. The importance of nitric oxide availability in myocardial ischemia-reperfusion injury : regulatory roles of arginase, L-arginine and tetrahydrobiopterin

    Författare :Yahor Tratsiakovich; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background. Maintenance of nitric oxide (NO) availability is crucial for cardiovascular homeostasis and protection against myocardial ischemia-reperfusion (IR) injury. LÄS MER

  7. 5. Endothelial dysfunction in atherosclerosis and type 2 diabetes : clinical and molecular studies of the role of endothelin and arginase

    Författare :Arnar Þór Rafnsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Atherosclerosis is a modern world scourge and the number of people worldwide diagnosed with type 2 diabetes (T2D) is on the rise, causing much morbidity and mortality. Endothelial dysfunction (ED) is an early sign of atherosclerosis and contributes to vascular complications in T2D. LÄS MER