Sökning: "amide"

Visar resultat 16 - 20 av 165 avhandlingar innehållade ordet amide.

  1. 16. Development of New Chiral Bicyclic Ligands : Applications in Catalytic Asymmetric Transfer Hydrogenation, Epoxidations, and Epoxide Rearrangements

    Författare :Arnaud Gayet; Andersson Pher G.; Hilmersson Göran; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; asymmetric catalysis; transfer hydrogenation; epoxide rearrangement; Organocatalysed epoxidation; chiral ligand; allylic alcohol; kinetic resolution; lithium amide; Organisk kemi; Organic chemistry; Organisk kemi;

    Sammanfattning : This thesis describes the synthesis and application of new chiral bicyclic ligands and their application in asymmetric catalysis. The studies involved: [i] The development of novel chiral bicyclic amino sulfur ligands and their use in transfer hydrogenation. LÄS MER

  3. 17. New approaches to preparation of macroporous monoliths for use in liquid chromatography

    Författare :Anh Mai Nguyen; Knut Irgum; Tatiana B. Tennikova; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; monolith; polycondensation; dissolution-precipitation; epoxy-amine; poly-amide; nylon; emulsion polymerization; characterization; protein separation; liquid chromatography; Analytical chemistry; Analytisk kemi; analytisk kemi; Analytical Chemistry;

    Sammanfattning : High performance liquid chromatography (HPLC) is one of the major techniques in separat-ion sciences. Faster separation and higher efficiency are required to meet ever-growing demands. Despite numerous studies and achievements on improving mass transfer in particulate packings discontinuity seems to be the cornerstone drawback in their development. LÄS MER

  4. 18. On the Versatility of Microwave-Assisted Chemistry : Exemplified by Applications in Medicinal Chemistry, Heterocyclic Chemistry and Biochemistry

    Författare :Kristina M. Orrling; Mats Larhed; Fredrik Almqvist; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; microwave-assisted chemistry; malaria; aspartic protease; plasmepsin; PfPM4; PmPM4; PoPM4; PvPM4; inhibitor; unsaturated lactone; unsaturated lactam; unsaturated amide; lactam; Bestmann s ylide; ionic liquid; polymerase chain reaction; thermophilic enzyme; Pharmaceutical chemistry; Läkemedelskemi; Organic synthesis; Organisk syntes; Biochemistry; Biokemi; Biochemistry; biokemi;

    Sammanfattning : Today, the demand for speed in drug discovery is constantly increasing, particularly in the iterative processes of hit validation and expansion and lead optimization. Irradiation with microwaves (MWs) has been applied in the area of organic synthesis to accelerate chemical reactions and to facilitate the generation of new chemical entities since 1986. LÄS MER

  5. 19. Rational engineering of esterases for improved amidase specificity in amide synthesis and hydrolysis

    Författare :Peter Hendil-Forssell; Mats Martinelle; Romas J. Kazlauskas; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Amidase; Biocatalysis; Enzyme; Esterase; Enzyme engineering; Lipase; Substrate specificity; Bioteknologi; Biotechnology;

    Sammanfattning : Biocatalysis is an ever evolving field that uses enzymes or microorganisms for chemical synthesis. By utilizing enzymes that generally have evolved for specific reactions under mild conditions and temperatures, biocatalysis can be a more environmentally friendly option compared to traditional chemistry. LÄS MER

  7. 20. Effect of the tri-peptide glycyl-prolyl-glycine amide on HIV-1 replication

    Författare :Jin Su; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1; antiretrovirals; peptides; tri-peptides; GPG-NH2; capsid formation; p24 dimerization; coneshaped core; GPG motif; V3 loop; infectivity;

    Sammanfattning : The human immunodeficiency virus type 1 (HIV-1) is the etiological agent responsible for AIDS worldwide. The aim of this thesis was to evaluate the anti-HIV-1 activity of short peptides and to investigate their mode of inhibition. LÄS MER