Sökning: "amide"

Visar resultat 11 - 15 av 165 avhandlingar innehållade ordet amide.

  1. 11. Amidst the green Metal-catalyzed amide formation from carboxylic acids

    Författare :Helena Lundberg; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : This thesis describes novel methods for transition metal-catalyzed transformation of non-activated carboxylic acids to amides. It was found that 2-10 mol% of zirconium(IV) chloride or 10-20 mol% titanium(IV) isopropoxide catalyzed the formation of a range of secondary and tertiary amides in good to excellent yields (61-99%) in THF at 70-100°C, with molecular sieves present as water scavengers. LÄS MER

  3. 12. The choreography of protein vibrations : Improved methods of observing and simulating the infrared absorption of proteins

    Författare :Eeva-Liisa Karjalainen; Andreas Barth; Astrid Gräslund; Timothy A. Keiderling; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Infrared spectroscopy; FTIR; protein; atpase; amyloid; caged compound; amide I; transition dipole coupling; exciton theory; simulation; Molecular biophysics; Molekylär biofysik; Biophysics; biofysik;

    Sammanfattning : The work presented in this thesis has striven toward improving the capability to study proteins using infrared (IR) spectroscopy. This includes development of new and improved experimental and theoretical methods to selectively observe and simulate protein vibrations. LÄS MER

  4. 13. Perfluroaryl azides : Reactivities, Unique Reactions and their Applications in the Synthesis of Theranostic Agents

    Författare :Sheng Xie; Mingdi Yan; Olof Ramström; Stefan Bräse; KTH; []
    Nyckelord :Click Chemistry; Dipolar Cycloaddition; Enamine; Triazoline; Amidine; Aggregation-induced emission; pure nanodrugs; aryl amide; thioacid azide reaction; nucleophilic aromatic substitution; azide-masked fluorophore; nitrene insertion; Kemi; Chemistry;

    Sammanfattning : The work centersaround perfluoroaryl azides (PFAAs), and theirability to undergo certain fast and robusttransformations. The chemistry was furtherappliedfor biomedical applications.The first section focuses on the azide-aldehyde-amine cycloaddition using PFAAs. LÄS MER

  5. 14. Asymmetric Formation and Isomerization of Three-Membered Rings : Catalyst Development and Evaluation

    Författare :Sophie Bertilsson; Tobias Rein; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; allylic alcohol; α-amino acid derivative; aza-Diels-Alder reaction; aziridination; cyclopropanation; desymmetrization; epoxide rearrangement; kinetic resolution; lithium amide; rhodium-carboxylate; Kemi; Chemistry; Kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : Enantiopure α-amino acid derivatives were prepared using a protocol which allows for highly controlled regio- and chemoselectivity in the hydrogenation/ hydrogenolysis of aza-Diels-Alder adducts. One of the resulting α-amino esters, (1S,3R,4R)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid ethyl ester, was utilized further as a catalyst precursor. LÄS MER

  7. 15. Fatty acid amide hydrolase - A target for anti-inflammatory therapies?

    Författare :Sandra Holt; Christopher J Fowler; Anders Bucht; Gunnar Tiger; Ruth A Ross; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; FAAH; anandamide; endocannabinoid; pH; inflammation; NSAID; Farmakologi; Pharmacological research; Farmakologisk forskning; medicinsk farmakologi; Medical Pharmacology;

    Sammanfattning : Anti-inflammatory drugs are a widely used class of therapeutic agents, but the use of non-steroidal anti-inflammatory drugs (NSAID) is hampered by their gastrointestinal side-effects. Recent reports that cyclooxygenase-2 inhibitors may cause cardiovascular events underline the importance of identifying new therapeutic strategies for the treatment of inflammation. LÄS MER