Sökning: "Viruses"

Visar resultat 1 - 5 av 518 avhandlingar innehållade ordet Viruses.

1. 1. Structural Decorations in Viruses : Unraveling Acquired Functional Structures in Icosahedral RNA Virus Capsids

   Författare :Han Wang; Kenta Okamoto; Sarah Butcher; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Viruses; RNA viruses; capsid; structure; cryo-EM; Molekylär biovetenskap; Molecular Life Sciences;

   Sammanfattning : Viruses have a profound impact worldwide, posing challenges to animal welfare, agriculture, human health, and the ecosystem. This thesis examines the realm of non-enveloped icosahedral double-stranded (ds)RNA and single-stranded (ss)RNA viruses through three studies. LÄS MER

3. 2. Cancer Immunotherapy : Oncolytic viruses and CAR-T cells

   Författare :Jing Ma; Di Yu; Magnus Essand; Mia Phillipson; Mohanraj Ramachandran; Karl-Johan Malmberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer immunotherapy; Oncolytic viruses; chimeric antigen receptor CAR -T cells; Helicobacter pylori Neutrophil Activating Protein;

   Sammanfattning : Various forms of cancer immunotherapy have developed rapidly with improved survival and quality of life for cancer patients. Cancer immunotherapy aims to educate the patient’s immune system to eliminate cancer cells, including immune checkpoint inhibitors (ICIs), adoptive cell transfer (mostly T cells), oncolytic viruses (OVs) and cancer vaccines. LÄS MER

4. 3. Exploring the diversity and evolution of giant viruses in deep sea sediments using genome-resolved metagenomics

   Författare :Disa Bäckström; Thijs J. G. Ettema; Anna J. Szekely; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Metagenomics; binning; viruses; NCLDV; Megavirales; viral evolution.;

   Sammanfattning : Viruses are the most abundant biological entities on this planet, which is impressive considering that they are completely dependent on their hosts for reproduction. Recently the idea of what viruses are has changed dramatically, with the discovery of giant viruses that belong to the Nucleocytoplasmic Large DNA Viruses (NCLDV), such as Mimiviridae, Marseilleviridae, and the proposed families Pandoraviruses, and Pithoviruses. LÄS MER

5. 4. Viruses on the wing : evolution and dynamics of influenza A virus in the Mallard reservoir

   Författare :Michelle Wille; Jonas Waldenström; Timm Harder; Linnéuniversitetet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Co-infections; Ecology; Epidemiology; Evolution; Host-Parasite Interactions; Immunity; Influenza A Virus; Mallard; Phylogeny; Virology; Waterfowl; Wild Birds; Wildlife Disease; Zoonotisk ekologi; Zoonotic Ecology;

   Sammanfattning : This thesis explores the evolution of avian influenza A viruses (IAV), as well as host-pathogen interactions between these viruses and their main reservoir host, the Mallard (Anas platyrhynchos). IAV is a genetically diverse, multi-host virus and wild birds, particularly dabbling ducks, are the natural reservoir. LÄS MER

7. 5. Genomic signatures in viruses

   Författare :Joel Gustafsson; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Virus evolution; Bioinformatics; Markov Chains; Genomic signatures;

   Sammanfattning : In an age of global pandemics, studying how viruses and their genomes evolve is of great importance. It has previously been found that the genomes of many eukaryotes and prokaryotes have specific preferences for nucleotides, dinucleotides, and codons. LÄS MER