Sökning: "VKORC1"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet VKORC1.

1. 1. Studies on warfarin treatment with emphasis on inter-individual variations and drug monitoring

   Författare :Abdimajid Osman; Tomas Lindahl; Peter Söderkvist; Marja-Liisa Dahl; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Warfarin; VKORC1; Haplotype; Prothrombin time; INR; Clinical chemistry; Klinisk kemi;

   Sammanfattning : Waran används sedan 60 år som blodförtunnande läkemedel för att förebygga eller förhindra progress av blodproppssjukdom. I Sverige behandlas årligen cirka 1 % av befolkningen med waran. I Östergötland uppskattas antal waranpatienter till cirka 3000. Waran hämmar enzymet VKORC1 som ansvarar för vitamin K omsättningen i kroppen. LÄS MER

3. 2. Two worlds, one goal : A Clinician’s Perspective on Laboratory Analyses in Anticoagulant Treatment

   Författare :Kerstin Arbring; Tomas Lindahl; Srinivas Uppugunduri; Margareta Holmström; Gerd Lärfars; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anticoagulants; Warfarin; DOAC; PT-INR; VKORC1;

   Sammanfattning : Almost precisely a century ago, in the 1920s and 1930s, cattle bled to death in North America after being fed moldy hay containing sweet clover, the yellow Melilotus officinalis, and the white Melilotus albus. The toxic substance in the hay inhibiting blood coagulation was identified and named dicumarol. LÄS MER

4. 3. On the Prediction of Warfarin Dose

   Författare :Niclas Eriksson; Mia Wadelius; Lars Wallentin; Lars Berglund; Patrik Magnusson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Warfarin; pharmacogenetics; prediction models; Dosing algorithm; GWAS; VKORC1; CYP2C9; Clinical Pharmacology; Klinisk farmakologi;

   Sammanfattning : Warfarin is one of the most widely used anticoagulants in the world. Treatment is complicated by a large inter-individual variation in the dose needed to reach adequate levels of anticoagulation i.e. INR 2. LÄS MER

5. 4. Major determinants of outcome and dosing in warfarin treatment

   Författare :Jonatan Lindh; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The aim of this thesis was to identify factors that determine individual patients sensitivity to the anticoagulant warfarin, and to quantify the effect of such factors on different measures of anticoagulation control. As part of this project, a large bio-bank was prospectively collected, with DNA and clinical data from more than 1500 patients starting warfarin treatment (the WARG cohort). LÄS MER

7. 5. Pharmacometric Models for Individualisation of Warfarin in Adults and Children

   Författare :Anna-Karin Hamberg; Mia Wadelius; E Niclas Jonsson; Lena E Friberg; Jeffrey S Barrett; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; warfarin; pharmacokinetics; pharmacodynamics; pharmacometrics; pharmacogenetics; dose individualisation; children; Klinisk farmakologi; Clinical Pharmacology;

   Sammanfattning : Warfarin is one of the most widely used anticoagulants. Therapy is complicated by warfarin’s narrow therapeutic range and pronounced variability in individual dose requirements. Although warfarin therapy is uncommon in children, it is crucial for children with certain congenital or acquired heart diseases. LÄS MER