Sökning: "VEGF"

Visar resultat 31 - 35 av 244 avhandlingar innehållade ordet VEGF.

  1. 31. Heparan Sulfate Regulation of Fibroblast Growth Factor (FGF) Receptor-1 Signal Transduction

    Författare :Lars Lundin; Lena Claesson-Welsh; Marco Presta; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; FGF; FGFR; dimerisation; signal transduction; heparan sulfate; proteoglycan; heparin; VEGF; embryonal stem cell; endothelial cell; differentiation; Patologi; Pathology; Patologi;

    Sammanfattning : Fibroblast growth factors (FGFs) constitute a family (currently FGF-1 to FGF-23) of polypeptides that are essential in embryonal development and adult physiology, in animals from nematodes to humans. FGFs bind to four receptor tyrosine kinases, denoted FGFR-1 to FGFR-4. LÄS MER

  3. 32. The Role of Histidine-rich Glycoprotein in Angiogenesis and Tumor Growth

    Författare :Åsa Thulin; Anna-Karin Olsson; Pirjo Laakkonen; Uppsala universitet; []
    Nyckelord :Histidine-rich glycoprotein; HRG HRGP HPRG; angiogenesis inhibitor; cancer; VEGF; platelets; MEDICINE; MEDICIN; Medicin; Medicine;

    Sammanfattning : Histidine-rich glycoprotein (HRG) is a heparin-binding plasma protein modulating immune, hemostatic and vascular functions. I have studied the antiangiogenic functions of HRG in vitro and in vivo in order to understand the molecular mechanisms of action of HRG as an angiogenesis inhibitor. LÄS MER

  4. 33. Biomolecule Functionalization of Diamond Surfaces for Implant Applications - A Theoretical Study

    Författare :Yuan Tian; Karin Larsson; Lars Ojamäe; Uppsala universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Diamond; Biomolecules; Functionalization; VEGF; BMP2; Fibronectin; Chitosan; Heparin; RGD peptide; Angiopoietin; Theoretical; Kemi med inriktning mot materialkemi; Chemistry with specialization in Materials Chemistry;

    Sammanfattning : Diamond is a promising material with unique chemical properties. In this thesis, nano-scale diamond quantum size effects were investigated using several chemical property indicators. LÄS MER

  5. 34. Molecular mechanisms of VEGF-mediated angiogenesis and vascular permeability

    Författare :Anna Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Angiogenesis; VEGF; vascular permeability;

    Sammanfattning : Angiogenesis, sprouting of new capillaries from pre-existing blood vessels, is a tightly regulated multi-step process. One of the key mediators in this process is the Vascular Endothelial Growth Factor (VEGF). Many tumors express high levels of VEGF and pathological angiogenesis is considered a hallmark of malignant tumor growth. LÄS MER

  7. 35. On VEGF and related factors in neurotrauma

    Författare :Mattias Sköld; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Spinal cord; brain; motoneuron; VEGF; VEGFR1; VEGFR2; Np1; Np2; Sema3A; HIF1alpha;

    Sammanfattning : At present, there is no cure for traumatic spinal cord and brain injuries. Therapies in use have only modest effect on outcome. Therefore, the need to better understand the biology of traumatic CNS injuries, making development of new therapies possible, is huge. LÄS MER