Sökning: "Ussing"

Visar resultat 1 - 5 av 38 avhandlingar innehållade ordet Ussing.

1. 1. Drug Transport and Metabolism in Rat and Human Intestine

   Författare :Sofia Berggren; Hans Lennernäs; Janet Hoogstraate; Patrick Augustijns; Uppsala universitet; []
   Nyckelord :Biopharmacy; Ussing chamber; microsome; single-pass perfusion; human; rat; intestine; permeability; efflux; P-glycoprotein; metabolism; cytochrome P450; ropivacaine; lidocaine; bupivacaine; Biofarmaci; PPX;

   Sammanfattning : One of the aims of this thesis was to investigate the involvement of efflux proteins, such as the P-glycoprotein (Pgp), in the drug transport in different regions of the rat and the human intestine. The intestinal extrusion of intracellularly formed CYP3A4 metabolites, including whether this extrusion might be mediated by Pgp, was also studied. LÄS MER

3. 2. Non-digestible Polysaccharides and Intestinal Barrier Function : specific focus on its efficacy in elderly and patients with Crohn’s disease

   Författare :John-Peter Ganda Mall; Robert Jan Brummer; Ida Schoultz; Åsa Keita; Mikael Wirén; Örebro universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Non-digestible polysachharides; beta-glucan; arabinoxylan; barrier function; permeability; Ussing chamber; elderly; Crohn’s disease;

   Sammanfattning : A large number of elderly suffer from gastrointestinal (GI) symptoms such as constipation and diarrhoea. The underlying mechanisms of age-acquired GI symptoms are not well studied but are necessary to clarify in order to recommend the right treatment. LÄS MER

4. 3. Epithelial barrier dysfunction in ileal Crohn's disease

   Författare :Johan Dabrosin-Söderholm; Svante Nordgren; Linköpings universitet; []
   Nyckelord :acetylsalicylic add; confocal microscopy; Crohn s disease; cytoskeleton; electron microscopy; genetics; human; ileum; inflammatory bowel disease; intestinal absorption; intestinal mucosa; macromolecules; mitochondria; ovalbumin; permeability; sodium caprate; tight junctions; transcytosis; uncoupling agents; Ussing chamber; MEDICINE; MEDICIN;

   Sammanfattning : The study aimed at investigating the intestinal barrier in Crohn's disease, with special reference to epithelial responses to luminal stimuli, and to permeation of proteins.Ileal mucosa from patients undergoing intestinal resection was studied in vitro in Ussing chambers. LÄS MER

5. 4. SODIUM/IODIDE SYMPORTER-NIS Abundant and Important in Gastric Mucosa

   Författare :Malin Josefsson; Neurogastroenterologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ussing chamber; MNNG; gastric iodide secretion; ouabain; gastric cancer; sodium perchlorate; gastric NIS; bile duct cancer; Sodium iodide symporter;

   Sammanfattning : ABSTRACT Background: Iodine is essential for development and growth as a constituent in thyroid hormones. Biological mechanisms for iodide uptake and concentration are very important, espe-cially as iodine is a relatively scarce element. LÄS MER

7. 5. Intestinal barrier function in health and disease

   Författare :Pernilla Nejdfors; Biologiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; VIP.; PACAP; secretion; ion transport; urine reservoir; radiation therapy; ulcerative colitis; macromolecules; dextran; mannitol; Ussing chamber; Intestinal permeability; mucosa; Animal physiology; Djurfysiologi; Physiology; Fysiologi;

   Sammanfattning : The intestinal epithelium has the dual function of absorbing nutrients and water as well as being a barrier to potentially harmful substances such as macromolecules and bacteria. In the present thesis the barrier function of the intestinal mucosa was studied in vitro in Ussing diffusion chambers. LÄS MER