Sökning: "TGF beta"

Visar resultat 21 - 25 av 86 avhandlingar innehållade orden TGF beta.

  1. 21. TGF-beta signaling in carcinogenic transformation of breast epithelial cells, using proteomics

    Författare :Nimesh Bhaskaran; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Transforming growth factor-beta (TGFbeta) is a key regulator of cell proliferation, death, migration and differentiation. One of the features of TGFbeta signaling is to inhibit tumor growth at the early stage of cancer but promotes tumorigenesis at the advanced stage. LÄS MER

  3. 22. Structure-function studies of GDNF and other members of the TGF-beta superfamily

    Författare :Susanna Eketjäll; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The glial cell line-derived neurotrophic factor (GDNF) family is a distant subclass of the TGF-beta superfamily. The GDNF family of ligands, consisting of GDNF, neurturin (NTN), artemin (ART) and persephin (PSP), are potent survival and differentiation factors for neurons in the central and peripheral nervous systems. LÄS MER

  4. 23. Genetic analysis of ligand-receptor interactions in the TGF-beta superfamily during early embryonic development

    Författare :Olov Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : During early development, cells differentiate and acquire specific fates according to their position in concentration gradients of morphogens. These substances often spread from a local region, termed an organizer, and exert different effects at distinct thresholds. LÄS MER

  5. 24. Mechanisms for Quantitative Regulation of TGF-ß Signaling

    Författare :Markus Dahl; Aristidis Moustakas; Carl-Henrik Heldin; Daniel Constam; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biologi med inriktning mot molekylär cellbiologi; Biology with specialization in Molecular Cell Biology;

    Sammanfattning : Cancer is a widely spread disease, and many cancer variants are today still difficult to treat. Efforts are being made to understand the complexity of cancer, both at a clinical level but also at a pre-clinical level. LÄS MER

  7. 25. Studies of the tumor-vasculature interface : role of TGF-beta 1-induced epithelial to mesenchymal transition

    Författare :Mei-Fong Pang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Tumor metastasis is a complex multistep process. Among key steps that occur during metastatic spread are acquisition of tumor cell motility, intravasation of tumor cells into blood or lymphatic vessels and extravasation of tumor cells at distal sites. However, the precise mechanisms that govern these metastatic steps remain elusive. LÄS MER