Sökning: "T-antigen"

Visar resultat 1 - 5 av 21 avhandlingar innehållade ordet T-antigen.

  1. 1. DNA and protein interactions of mouse polyomavirus large T antigen

    Författare :Ola Rönn; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; T-antigen; DNA-binding; biosensor; enhancer; Biokemi; Biochemistry; Biokemi; Medical Virology; medicinsk virologi;

    Sammanfattning : Polyomaviruses require dividing cells to multiply. The regulatory genes express proteins, theT-antigens, necessary for this to occur. Large T-antigen (LT), is a phosphoprotein withmultiple intrinsic activities, e.g. LÄS MER

  3. 2. Mouse polyomavirus large T-antigen : DNA-binding and related activities

    Författare :Kåre Bondeson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  4. 3. Studies on the Molecular Biology of the Mouse Pneumotropic Polyomavirus

    Författare :Shouting Zhang; Kristina Dörries; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; murine pneumotropic virus; Kilham mouse polyomavirus; large T antigen; enhancer; regulatory region rearrangement; gene expression regulation; DNA replication; transposable elements; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : The Murine Pneumotropic Virus (MPtV), in contrast to the other MurinePolyomavirus (MPyV), appears to be non-tumourigenic in its natural host. Instead, MPtV causes acute pneumonia and can serve as a model in studies of polyomavirus-induced disease. In initial experiments, MPtV large T-antigen (LT) was expressed in a heterologous system. LÄS MER

  5. 4. Viral Strategies to Regulate Transcription and Pre-mRNA Splicing

    Författare :Shaoan Fan; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Adenovirus E1B-55kDa; E4-ORF4; E4-ORF6 proteins; L1 mRNA; Polyoma virus small T antigen; regulation; transcription; splicing; PP2A; Biokemi; Biochemistry; Biokemi; Medical Virology; medicinsk virologi;

    Sammanfattning : A typical DNA virus encodes for a few key regulatory proteins that modify the host cell biosynthetic machinery to achieve a selective viral gene statement. One such example is illustrated by the adenovirus E4-ORF4 protein, which form an enzymatically active complex with the serine and threonine-specific protein phosphatase 2A (PP2A). LÄS MER

  7. 5. Persistence of polyomavirus : versus immunity to polyoma tumors

    Författare :Zsofia Berke; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :polyomavirus persistence; CD4--; CD8--; IgM--; XID; SCID; TSTA; T-antigen; tumor rejection.;

    Sammanfattning : The aim of this thesis was to understand the role of different specific immune effectors with regard to polyomavirus persistence and polyomavirus induced tumor development. Furthermore, an MHC class I restricted short viral peptide was identified as a target for polyomavirus specific recognition of polyoma tumor cells. LÄS MER