Sökning: "Structural conditions"

Visar resultat 1 - 5 av 1205 avhandlingar innehållade orden Structural conditions.

  1. 1. Structural and functional studies of proteins of medical relevance : Protein-ligand complexes in cancer and novel structural folds in bacteria

    Författare :Robert Gustafsson; Pål Stenmark; Pavlína Řezáčová; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; X-ray crystallography; Cancer; MTH1; oxidised nucleotides; MTHFD2; nucleotide metabolism; one-carbon metabolism; Botulism; Botulinum neurotoxin; OrfX; OrfX gene cluster; Biochemistry; biokemi;

    Sammanfattning : X-ray crystallography is a tool for determining the structures of proteins and protein-ligand complexes. In this thesis the method has been employed to study several proteins of medical relevance.Cancer is a terrible disease, severely impacting those affected, as well as their family and friends. LÄS MER

  3. 2. Structural assessment procedures for existing concrete bridges : Experiences from failure tests of the Kiruna Bridge

    Författare :Niklas Bagge; Björn Täljsten; Paulo Cruz; Luleå tekniska universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Anchorage; carbon fibre reinforced polymers; concrete; existing bridges; finite element analysis; flexure; full-scale test; load-carrying capacity; residual prestress force; punching; safety verification; shear; structural assessment; structural behaviour; Structural Engineering; Konstruktionsteknik;

    Sammanfattning : Assessing existing bridges is an important task in the sustainable management ofinfrastructure. In practice, structural bridge assessments are usually conducted usingtraditional and standardised methods, despite knowledge that these methods oftenprovide conservative estimates. LÄS MER

  4. 3. Structural biology studies of thylakoid lumen proteins required for photosystem II assembly and function

    Författare :Roland Locmelis; Uwe Sauer; Wolfgang Schröder; Inger Andersson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; structural biology; x-ray crystallography; cloning; protein expression; HCF136; LPA19; MPH2; Prx6; photosynthesis; thylakoid lumen PSII;

    Sammanfattning : Little is known about the structures and functions of thylakoid lumen proteins. However, some of these proteins have an essential role in photosynthesis. LÄS MER

  5. 4. Combined structural methods to characterize an oligomeric small heat shock protein Hsp21

    Författare :Gudrun Rutsdottir; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Small heat shock proteins; chaperones; crosslinking mass spectrometry; Stable isotope labeling; quantification; small angle X-ray scattering; cryo-electron microscopy; combined structural methods; plant stress;

    Sammanfattning : Small heat shock proteins (sHsps) are found in all organisms and evolved early in the history of life, prior to the divergence of the three domains of life (Archaea, Bacteria, and Eukarya). Their malfunction is connected to several different diseases in humans, such as Alzheimer’s and Parkinson’s disease. LÄS MER

  7. 5. Structural transitions of proton-gated ion channels : Involving pH sensing, heterogeneity and lipid interactions

    Författare :Urška Rovšnik; Erik Lindahl; Hugues Nury; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ion channels; cryo-electron microscopy; pH gating; simulations; structure-function relationship; GLIC; DeCLIC; biokemi; Biochemistry;

    Sammanfattning : Studying protein structure and function involves analyzing the relationship between a protein's three-dimensional assembly and its dynamic biochemical activity. The superfamily of pentameric ligand-gated ion channels (pLGICs) constitutes a classic yet illuminating experimental system for structure-function studies. LÄS MER