Sökning: "Stem cell-derived islets"

Hittade 5 avhandlingar innehållade orden Stem cell-derived islets.

1. 1. Physiological Studies of Native and Stem Cell-Derived Islets

   Författare :Daniel Norman; Per-Ola Carlsson; Daniel Espes; Helge Ræder; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Irisin; CART; Islet blood flow; Islets of Langerhans; Stem cell-derived islets; Fysiologi; Physiology; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : In type 1 and type 2 diabetes, the β-cells of the islets of Langerhans are either destroyed by the immune system or stressed due to peripheral insulin resistance. To improve the life of patients with these diseases, new treatments are needed. LÄS MER

3. 2. Transplantation of stem cell-derived islets as a treatment for type 1 diabetes

   Författare :Julia Thorngren; Joey Lau Börjesson; Per-Ola Carlsson; Lena Eliasson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Islet of Langerhans; Stem cell-derived islets; Islet transplantation; Humanized mouse model; Positron emission tomography; Nanofiltration; Fysiologi; Physiology; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Type 1 diabetes (T1D) is an autoimmune disease that leads to an immune attack on insulin-producing beta cells, necessitating lifelong insulin therapy. For individuals with brittle diabetes and poor metabolic control, the option of pancreatic human islet transplantation exists. LÄS MER

4. 3. Pancreatic extracellular communication. Applications to beta cell cultures and islet amyloid polypeptide aggregation

   Författare :Diana Ribeiro; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; in vitro pancreatic models; induced pluripotent stem cells; stem cell differentiation; insulin; 3D-culture; extracellular vesicles; glucose-stimulated insulin secretion; islet amyloid polypeptide; type 2 diabetes mellitus; extracellular matrix; adipose-derived stem cells; Diabetes mellitus; protein aggregation;

   Sammanfattning : Diabetes mellitus (DM) is a disease with epidemic proportions due to increased incidences worldwide, persistence of undiagnosed cases, uncontrolled forms of the disease, association with cardiovascular complications, and lack of definitive treatment options. In particular, type 2 DM (T2DM) is placing an enormous financial burden on worldwide healthcare systems that will increase in the futureThere is a need to develop physiological assay platforms that provide functionally relevant models of diabetes in order to accelerate the discovery of new treatments. LÄS MER

5. 4. The role of T-type calcium channels in human pancreatic β cell maturity

   Författare :Kaixuan Zhao; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : This PhD work has optimized a series of in vivo, ex vivo and in vitro approaches to recapitulate, intervene and appraise in vivo maturation of naïve β cells within human induced pluripotent stem cell-derived islets (hiPSC-islets). These approaches have also been applied to characterize hyperglycemia-induced dedifferentiation of mature β cells within native human islets grafted into the anterior chamber of the eye (ACE) of immunodeficient mice. LÄS MER

7. 5. Engraftment and tolerance induction in cellular therapy : focus on mesenchymal stromal cells

   Författare :Karin Ljung; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Different cell types have been employed in the search for a cellular therapy that is applicable for the treatment of heart failure. Remuscularization strategies using stem-cell-derived cardiomyocytes have been prone to arrhythmias. LÄS MER