Sökning: "Stefan Schwartz"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden Stefan Schwartz.

  1. 1. The balance of splicing : A novel insight into the splicing regulation of high-risk HPV E6 and E7 oncogenes

    Författare :Johanna Jönsson; Naoko Kajitani; Stefan Schwartz; Ola Forslund; Francesca Aguilo; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; HPV; splice donor; splice acceptor; cis-element; trans-acting factor; pre-mRNA splicing; splicing regulation.; Medical Virology; Medicinsk virologi;

    Sammanfattning : HPV is associated with several cancers. The genome consists of a long control region, early (E1, E2, E4, E5, E6 and E7) and late (L1 and L2) genes. The E6 and E7 proteins prevent cells from entering apoptosis and regulate the cell cycle. A deregulated expression of these can result in malignant transformations. LÄS MER

  3. 2. Human adenovirus – host cell interplay : The role of the cellular zinc finger proteins and mitochondrial DNA

    Författare :Kwangchol Mun; Tanel Punga; Stefan Schwartz; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Adenovirus; Protein VII; Ubiquitination; Chromatin remodeling; Mitochondria;

    Sammanfattning : Human adenovirus (HAdV) is an abundant DNA virus with significant clinical relevance since it cauces a variety of respiratory, ocular, and gastrointestinal diseases. It is also intensively used as a therapeutic tool to treat cancers and to boost immune responses. LÄS MER

  4. 3. Capsid protein functions of enteric human adenoviruses

    Författare :Anandi Rajan; Niklas Arnberg; Stefan Schwartz; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adenovirus; gastroenteritis; capsid proteins; receptor; integrins; heparan sulfate; sialic acid;

    Sammanfattning : Human adenoviruses (HAdVs) cause respiratory illnesses, epidemic conjunctivitis and infantile gastroenteritis. HAdV types 40 and 41 cause enteric infections in infants worldwide. HAdVs use various receptors for attachment onto different host cells. LÄS MER

  5. 4. Regulation of RNA Processing in Human Papillomavirus Type 16

    Författare :Margaret Rush; Stefan Schwartz; Jörgen Kjems; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; RNA processing; human papillomavirus; HPV-16; alternative splicing; polyadenylation; exonic splicing enhancer; 3 UTR; upstream polyadenylation element; SR proteins; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Sammanfattning : Human papillomavirus type 16 (HPV-16) is the major cause of cervical cancer. HPV-16 gene expression is tightly linked to the differentiation programme of the infected epithelium. Expression of the late genes, L1 and L2, encoding the capsid proteins, is delayed until the more terminally differentiated cells. LÄS MER

  7. 5. Cellular and Viral Factors that Control Human Papillomavirus Type 16 Late Gene Expression

    Författare :Monika Somberg; Stefan Schwartz; Sheila Graham; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virology; Virologi; Medical Virology; Medicinsk virologi;

    Sammanfattning : Human papillomavirus type 16 (HPV-16) is the major cause of cervical cancer. We speculate that inhibition of HPV-16 late gene expression is a prerequisite for establishment of persistence and progression to cervical cancer. LÄS MER