Sökning: "Somatosensory system"

Visar resultat 1 - 5 av 54 avhandlingar innehållade orden Somatosensory system.

  1. 1. Somatosensory Circuits in the Central Nervous System

    Författare :Hannah M. Weman; Malin C. Lagerström; Sarah E. Ross; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glycine receptor alpha 3; urocortin 3; vesicular monoaminergic transporter 2; nociception; pruriception; spinal cord; somatosensory cortex; DREADD; rabies tracing; transcriptomics; Neuroscience; Neurovetenskap;

    Sammanfattning : Spinal glycinergic neurons prevent spontaneous sensations of pain and itch, and development of persistent pain and itch conditions. The glycine receptor alpha 3 subunit (GLRA3) is suggested to be involved in certain inflammatory models, but not in acute nociception. LÄS MER

  3. 2. Deciphering neural networks in the somatosensory system using single-cell transcriptomics and rabies tracing

    Författare :Jon E. T. Jakobsson; Malin C. Lagerström; Victoria Abraira; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; neural networks; somatosensory system; itch; rabies tracing; scRNA-seq;

    Sammanfattning : Itch has evolved to protect us from malicious parasites keen to suck our blood or lay their eggs in our skin. We can detect both the movement of these parasites and the toxins they introduce with specialized neurons called pruriceptors. When we feel an itch, we get a desire to scratch it. LÄS MER

  4. 3. Information Processing in the Nervous System. On a Holistic Functional Organization Principle

    Författare :Jonas Enander; Hjärnans sensorimotoriska funktioner; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Somatosensory; Tactile; Neuron; Neocortex; Brain organization; Cortical functional localization;

    Sammanfattning : This thesis is concerned with the nature of information processing in the nervous system. This issue has been investigated with animal experiments, using male Sprague–Dawley rats, and simulated touch generated by an artificial fingertip with neuromorphic tactile sensors. LÄS MER

  5. 4. Spontaneous Movements during Sleep Guide Spinal Self-organization: Formation and Expression of a Memory Trace

    Författare :Per Petersson; Neurofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurologi; neuropsychology; Neurology; long-term memory; somatosensory; receptive field; learning; sensorimotor; developmental; neurophysiology; neurofysiologi; neuropsykologi;

    Sammanfattning : During development, information about the three-dimensional shape and mechanical properties of the body is laid down in the synaptic connectivity of sensorimotor systems through adaptive mechanisms. In spinal reflex systems, this enables the fast transformation of complex sensory information into adequate correction of movements. LÄS MER

  7. 5. Targeting and driving somatosensory neurons

    Författare :Fabio Freitag; Malin C. Lagerström; Andrew Todd; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pain; Itch; GRPR interneurons; dorsal horn; trigeminal nucleus caudalis; Barrel field;

    Sammanfattning : Pain and itch are two distinct sensations, but the fundamental question of how our nervous system distinguishes the processing and encoding of their related information is still far to be clearly delineated. At the spinal cord level, evidences have pointed out specific groups of neurons expressing the gastrin releasing peptide (Grp) and its receptor (Grpr) as responsible for carrying specifically itch-related information. LÄS MER