Sökning: "SP1-7"

Hittade 5 avhandlingar innehållade ordet SP1-7.

1. 1. The Impact of the Neuropeptide Substance P (SP) Fragment SP1-7 on Chronic Neuropathic Pain

   Författare :Anna Jonsson; Fred Nyberg; Mathias Hallberg; James Zadina; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropathic pain; substance P SP ; SP1-7; bioactive fragments; spared nerve injury; spinal cord injury; streptozotocin-induced diabetes; allodynia; hyperalgesia; peptidomimetics; cerebrospinal fluid; spinal cord stimulation; radioimmunoassay; Pharmaceutical Science; Farmaceutisk vetenskap;

   Sammanfattning : There is an unmet medical need for the efficient treatment of neuropathic pain, a condition that affects approximately 10% of the population worldwide. Current therapies need to be improved due to the associated side effects and lack of response in many patients. LÄS MER

3. 2. The Impact of Substance P (SP) N-Terminal Metabolite SP1-7 in Opioid Tolerance and Withdrawal

   Författare :Qin Zhou; Tsukasa Sakurada; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk biokemi; Pharmaceutical Biochemistry;

   Sammanfattning : The heptapeptide SP1-7, a metabolite of the neuroactive peptide substance P (SP), is suggested to play a role in opioid addiction and memory function. These two dimensions are known to involve dopamine and glutamate transmissions mediated through dopamine receptors and N-methyl-D- aspartate (NNMA) receptors, respectively. LÄS MER

4. 3. Studies on the level of substance P and calcitonin gene-related peptide in cerebrospinal fluid of pregnant women and patients with chronic pain and in rat brain after spinal cord injury : Special reference to analytical aspects of neuropeptides

   Författare :Zhurong Liu; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Substance P; Calcitonin gene-related peptide; Radioimmunoassay; High performance liquidchromatography; Cerebrospinal fluid and chronic pain; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Pharmacognosy; farmakognosi;

   Sammanfattning : Substance P (SP) and calcitonin gene-related peptide (CGRP) are sensory peptides known to be involved innociception and inflammatory processes. It is well demonstrated that the two peptides can be released from spinal cord neurons during inflammation and chronic pain induced by peripheral nerve injury. LÄS MER

5. 4. Anabolic Androgenic Steroids : Effects on Neuropeptide Systems in the Rat Brain

   Författare :Mathias Hallberg; Fred Nyberg; Pierre Le Grevès; James Zadina; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biological research on drug dependence; Anabolic androgenic steroids; Nandrolone decanoate; Substance P; NK1 receptor; Substance P 1-7 ; Endopeptidase; Opioids; Calcitonin gene-related peptide; Radioimmunoassay; Autoradiography; Central nervous system; Rats; Biologisk beroendeforskning; Biological research on drug dependence; Biologisk beroendeforskning;

   Sammanfattning : Anabolic-androgenic steroids (AAS) have been used in clinics for decades. The misuse of AAS has previously been attributed merely to sport athletes, taking AAS with intentions to increase muscle mass, enhance physical performance and to improve results in competitions. LÄS MER

7. 5. Discovery of Small Peptides and Peptidomimetics Targeting the Substance P 1-7 Binding Site : Focus on Design, Synthesis, Structure-Activity Relationships and Drug-Like Properties

   Författare :Rebecca Fransson; Anja Sandström; John S Svendsen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; substance P 1-7; peptidomimetics; structure-activity relationship; drug-like properties; phenylalanine; imidazole; MAP aryl amides; carbonylation; Pharmaceutical chemistry; Farmaceutisk kemi; Medicinal Chemistry; Läkemedelskemi;

   Sammanfattning : Biologically active peptides are important for many physiological functions in the human body and therefore serve as interesting starting points in drug discovery processes. In this work the neuropeptide substance P 1–7 (SP1–7, H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-OH), which has been demonstrated to reduce neuropathic pain and attenuate opioid withdrawal symptoms in animal models, has been addressed in a medicinal chemistry program with the overall aim of transforming this bioactive peptide into more drug-like compounds. LÄS MER