Sökning: "Mathias Hallberg"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden Mathias Hallberg.

  1. 1. Anabolic Androgenic Steroids : Effects on Neuropeptide Systems in the Rat Brain

    Författare :Mathias Hallberg; Fred Nyberg; Pierre Le Grevès; James Zadina; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biological research on drug dependence; Anabolic androgenic steroids; Nandrolone decanoate; Substance P; NK1 receptor; Substance P 1-7 ; Endopeptidase; Opioids; Calcitonin gene-related peptide; Radioimmunoassay; Autoradiography; Central nervous system; Rats; Biologisk beroendeforskning; Biological research on drug dependence; Biologisk beroendeforskning;

    Sammanfattning : Anabolic-androgenic steroids (AAS) have been used in clinics for decades. The misuse of AAS has previously been attributed merely to sport athletes, taking AAS with intentions to increase muscle mass, enhance physical performance and to improve results in competitions. LÄS MER

  3. 2. Growth hormone in the brain : Focus on cognitive function

    Författare :Erika Brolin; Fred Nyberg; Mathias Hallberg; Alfhild Grönbladh; Jörgen Isgaard; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Growth hormone; central nervous system; cognition; morphine; gamma-hydroxybutyrate; diabetes; Barnes maze; Morris water maze; mice; rats; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : Cognitive impairments are an increasing health problem worldwide. In the developed countries, the average life expectancy has dramatically increased over the last decades, and with an elderly population more cases of cognitive impairments appear. LÄS MER

  4. 3. Growth Hormone and Anabolic Androgenic Steroids : Effects on Neurochemistry and Cognition

    Författare :Alfhild Grönbladh; Mathias Hallberg; Jörgen Isgaard; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Growth hormone; anabolic androgenic steroids; nandrolone decanoate; insulin-like growth factor; GABAB; opioids; memory; water maze; autoradiography; central nervous system; rats; Biological Research on Drug Dependence; Biologisk beroendeforskning;

    Sammanfattning : Growth hormone (GH) stimulates growth and metabolism but also displays profound effects on the central nervous system (CNS). GH affects neurogenesis and neuroprotection, and has been shown to counteract drug-induced apoptosis in the brain. LÄS MER

  5. 4. The Impact of Growth Hormone and Gamma-Hydroxybutyrate (GHB) on Systems Related to Cognition

    Författare :Jenny Johansson; Mathias Hallberg; Fred Nyberg; Linda Fryklund; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Growth Hormone; Gamma-Hydroxybutyrate; GABAB; Opioids; Insulin-like growth factor 1; Rats; Central Nervous System; Autoradiography; Radioimmunoassay; ELISA; Water Maze; Open Field; Biological Research on Drug Dependence; Biologisk beroendeforskning;

    Sammanfattning : Drug dependence is a serious and increasing problem in our society, especially among adolescents. The use of the large variety of substances available can result in a range of physiological and psychological adverse effects on individuals and negative consequences on the society overall. LÄS MER

  7. 5. The Impact of the Neuropeptide Substance P (SP) Fragment SP1-7 on Chronic Neuropathic Pain

    Författare :Anna Jonsson; Fred Nyberg; Mathias Hallberg; James Zadina; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropathic pain; substance P SP ; SP1-7; bioactive fragments; spared nerve injury; spinal cord injury; streptozotocin-induced diabetes; allodynia; hyperalgesia; peptidomimetics; cerebrospinal fluid; spinal cord stimulation; radioimmunoassay; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : There is an unmet medical need for the efficient treatment of neuropathic pain, a condition that affects approximately 10% of the population worldwide. Current therapies need to be improved due to the associated side effects and lack of response in many patients. LÄS MER