Sökning: "SDF-1"

Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet SDF-1.

1. 1. Regulation of human mast cell development

   Författare :Malin Hjertson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Mast cells; hematopoiesis; chemotaxis; SCF; FL; GM-CSF; IL-3; RA; SDF-1; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

   Sammanfattning : Mast cells are multifunctional effector cells of the immune system and are best known for theirparticipation in allergic reactions. The aim of this thesis was to investigate how the stem cell factor(SCF)-dependent development of mast cells from cord blood can be regulated by different factors, and tostudy how immature mast cells circulating in the blood can be recruited into the tissue. LÄS MER

3. 2. Endothelial cells : dysfunction and repair mechanisms

   Författare :Elzafir Elsheikh; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Endothelial cells; endothelial progenitor cells; Wegener s granulomatosis; atherosclerosis; myocardial infarction; menstruation cycle; stromal cell-derived factor-1;

   Sammanfattning : Endothelial cells (ECs) are crucial component of the normal vascular wall, providing an interface between the bloodstream and surrounding tissue of the blood vessel wall. Endothelial progenitors cells (EPCs) circulate in the blood and migrate to regions of the circulatory system with injured endothelium and ischemic tissues. LÄS MER

4. 3. Regulation of antibody production in immunocompromised patients

   Författare :Anna Nilsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Hypergammaglobulinemia; specific antibodies; memory B- cells; microenvironment;

   Sammanfattning : The aim of this thesis was to study B-cell function and the regulation of specific antibody (Abs) production in immunocompromised individuals. As models, we have studied children with acute lymphoblastic leukaemia (ALL) and patients with IRV-I infection. LÄS MER

5. 4. Angiogenetic and hereditary factors in endometrial disease

   Författare :Emil Andersson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The endometrium is a unique tissue in the adult human body because it is the only site where physiological renewal of vessels, angiogenesis, occurs. The regulation of this process under normal conditions is not fully understood. LÄS MER

7. 5. Long-term neurogenesis after stroke in the adult rat brain

   Författare :Pär Thored; Lund Neurologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; embryologi människa ; Neurology; neuropsychology; neurophysiology; Utvecklingsbiologi; teratologi; embryology human ; ontogeny; Development biology; teratology; Stroke; Stem Cells; Neurogenesis; neurofysiologi; Clinical biology; Klinisk biologi; Neurologi; neuropsykologi;

   Sammanfattning : Stroke is a leading cause of death and disability for which there is no treatment for functional recovery. Following stroke, striatal neurogenesis is increased, with newly formed neuroblasts migrating towards the damage. This response has so far been considered acute and transient. LÄS MER