Sökning: "Raffaele De Francesco"

Hittade 1 avhandling innehållade orden Raffaele De Francesco.

1. 1. Kinetic studies of NS3 and NS5B from Hepatitis C virus : Implications and applications for drug discovery

   Författare :Göran Dahl; Helena Danielson; Raffaele De Francesco; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatitis C virus; NS3; NS5B; enzyme kinetics; inhibition; resistance; drug; Biochemistry; Biokemi; Biokemi; Biochemistry;

   Sammanfattning : The aim of these studies was to increase our understanding of the non-structural proteins 3 and 5B (NS3 and NS5B) from the hepatitis C virus (HCV), and thereby contribute to the development of new and better drugs against HCV.By studying NS3 with substitutions identified to be associated with resistance to NS3 inhibitors in clinical trials (R155Q, A156T and D168V) it was found that not all inhibitors were affected, indicating that cross-resistance can be avoided. LÄS MER