Sökning: "RNA load"

Visar resultat 21 - 25 av 60 avhandlingar innehållade orden RNA load.

  1. 21. Nucleic acid-based detection and characterization of hepatitis C virus

    Författare :Zhibing Yun; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HCV; PCR; genotype; HVRI; heterogeneity; IFN-a; immunodeficiency;

    Sammanfattning : Nucleic acid-based methods were developed to detect and characterize the HCV genome in immunocompetent and immunodeficient patents of whom some were IFN-a treated. HCV RNA was found in most sera (95%), livers (97%) and PBMC (100%) of patients with confirmed chronic hepatitis, but also in sera (21%) of patients with indeterminate confirmatory antibody test, especially those with c22 antigen reactivity. LÄS MER

  3. 22. Studies on the efficacy of potent anti-HIV-1 therapy on virological and immunological factors

    Författare :Soo Aleman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The aim of this thesis was to assess to which extent treated human immunodeficiency virus type I (HIV-1) infected patients with a seemingly controlled, defined as undetectable plasma HIV-1 RNA levels (< 50 copies/ml), or low-grade viral replication, exhibited pattems in virological and immunological factors which could suggest a continuation of the disease process. We have therefore analysed the kinetics of HIV-1 DNA levels (Papers I and II), the viral evolution (Paper II), the changes in Beta-chemokine levels (Paper 111) and sCD27 levels (Paper IV), and the appearance of drug resistance associated mutations (Paper V) in such patients. LÄS MER

  4. 23. Hepatitis B virus replication and integration

    Författare :Simon B. Larsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatitis B virus; replication; integration; HBV DNA; HBsAg;

    Sammanfattning : Chronic infection with hepatitis B virus (HBV) affects 240 million people worldwide and may cause liver disease including hepatocellular carcinoma (HCC). Initially patients have high levels of HBV DNA in their blood, no liver disease and express the e antigen (HBeAg). LÄS MER

  5. 24. Methods for detection of HIV-2/SIV infections

    Författare :Lilian Walther Jallow; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The main objective of this thesis was to develop and improve laboratory methods for detection of HIV-2 in infected humans and detection of HIV-2/SIV in experimentally infected cynomolgus monkeys. Early in the HIV epidemic no assays were commercially available for detection of HIV-2/SIV infections and laboratory testing often relied on cross-reactivity in the assays. LÄS MER

  7. 25. Hepatitis C virus. Aspects on natural history, antibody response, and viral quantification

    Författare :Martin Lagging; Göteborgs universitet; []
    Nyckelord :Hepatitis C virus; nosocomial infection; pseudotyped virus; fibrosis; viral quantification;

    Sammanfattning : Hepatitis C virus (HCV) is the major cause of parenterally transmitted non-A, non-B hepatitis, and is associated with chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Despite the screening of blood products nosocomial spread of HCV continues to occur. LÄS MER