Sökning: "RNA load"

Visar resultat 6 - 10 av 60 avhandlingar innehållade orden RNA load.

  1. 6. Antiretroviral treatment of HIV-1 in the central nervous system

    Författare :Aylin Yilmaz; Göteborgs universitet; []
    Nyckelord :HIV-1; cerebrospinal fluid; antiretroviral treatment; lopinavir; saquinavir; nelfinavir; neopterin; beta-2-microglobulin; HIV-1 RNA; IgG index; blood-brain barrier; albumin ratio; ultra-ultra sensitive PCR;

    Sammanfattning : HIV-1 invades the central nervous system (CNS) early in the infectious course. It establishes a chronic progressive infection, and triggers an intrathecal immune response. If left untreated, a majority of patients will develop neurological complications, caused by opportunistic pathogens or HIV-1 itself. LÄS MER

  3. 7. The zoonotic pathogen Borrelia afzelii in its natural hosts : Bacterial dissemination and immuno-transcriptomics

    Författare :Xiuqin Zhong; Funktionell zoologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Borrelia afzelii; natural hosts; bacterial load; immune response; RNA-seq;

    Sammanfattning : Most pathogens can infect a number of different host species, but host species often differ considerably in susceptibility to a given pathogen. In the case of zoonotic pathogens, natural hosts typically present little or no disease symptoms, while humans and other “spill-over” hosts often present severe symptoms. LÄS MER

  4. 8. HIV therapies : from health-related quality of life to DNA levels

    Författare :Lars E Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :AIDS; antiretroviral therapy; CD4; DNA load; HIV; immunotherapy; viral kinetics; nursing; medical care; quality of life; real-time PCR; rgpl60; RNA load; therapy interruption.;

    Sammanfattning : The treatment of people infected with HIV was revolutionised with the introduction of protease inhibitor based antiretroviral combination therapy. The therapy has greatly reduced the incidence of AIDS and AIDS-related mortality in the industrialised world. LÄS MER

  5. 9. Hepatitis C virus kinetics during antiviral treatment

    Författare :Tony Carlsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Hepatitis C virus RNA; genotype; kinetics; interferon-alpha; ribavirin.;

    Sammanfattning : It is estimated that 170 million individuals have chronic hepatitis C virus (HCV) infection, whereof 20-30% will develop end stage liver disease within 20-30 years. Antiviral therapy can stop this deterioration and clear the infection in 40-80% of the patients depending on treatment and HCV genotype. LÄS MER

  7. 10. Strategies of gene and immune therapy for tumors and viral diseases

    Författare :Herman José Arteaga; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Intracellular cytokines; DNA vaccine-GM-CSF; HIV- 1; RNA interference;

    Sammanfattning : In the treatment of tumors and viral diseases such as HIV-1 infection, immunotherapeutic strategies do not seem to have enough capacity to eradicate an already established disease. However, these strategies could play a unique role as adjuvant treatments of therapies that eliminate the main tumor or viral load in order to avoid the relapse of the disease. LÄS MER