Sökning: "Proximity Extension Assay PEA technology"

Hittade 4 avhandlingar innehållade orden Proximity Extension Assay PEA technology.

1. 1. Biomarkers for Better Understanding of the Pathophysiology and Treatment of Chronic Pain : Investigations of Human Biofluids

   Författare :Anne-Li Lind; Torsten Gordh; Masood Kamali-Moghaddam; Jonas Bergquist; Eva Kosek; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; chronic pain; neuropathic pain; lumbar radicular pain; amyotrophic lateral sclerosis; radiculopathy; fibromyalgia; pathophysiology; spinal cord stimulation; mechanism of action; disc herniation; cerebrospinal fluid; plasma; biomarker; human; protein; chemokines; cytokines; inflammation; neuroinflammation; mass spectrometry; proximity ligation assay; proximity extension assay; antibody suspension bead array; protein profiling; molecular medicine; personalized medicine; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care; Biomedical Laboratory Science; Biomedicinsk laboratorievetenskap; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry; Medicinsk vetenskap; Medical Science; Molekylär medicin; Molecular Medicine;

   Sammanfattning : Chronic pain affects 20 % of the global population, causes suffering, is difficult to treat, and constitutes a large economic burden for society. So far, the characterization of molecular mechanisms of chronic pain-like behaviors in animal models has not translated into effective treatments. LÄS MER

3. 2. Advanced molecular tools for diagnostic analyses of RNA and antibodies in situ and in solution

   Författare :Mengqi Wang; Ulf Landegren; Anders Ståhlberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Homogenous serological assay; PCR-based antibody detection; Proximity extension assay; SARS-CoV-2 antibody; Extracellular vesicles; Proximity barcoding assay; in situ superRCA; mutant transcript;

   Sammanfattning : Advanced molecular diagnostics uses in vitro biological assays to detect nucleic acids or proteins even in low concentrations across samples, allowing for the identification of biomarkers, monitoring the course of the disease over time, and selection of appropriate therapy. In this thesis, I focus on development and early applications of several molecular tools of expected value in research, and eventually also clinically. LÄS MER

4. 3. Studies on inflammation in the acute phase of aneurysmal Subarachnoid Hemorrhage

   Författare :Pavlos Vlachogiannis; Elisabeth Ronne-Engström; Lars Hillered; Johan Wikström; Bo-Michael Bellander; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; subarachnoid hemorrhage SAH ; inflammation; Delayed Cerebral Ischemia DCI cerebral vasospasm; Proximity Extension Assay PEA technology; Neurokirurgi; Neurosurgery;

   Sammanfattning : Spontaneous subarachnoid hemorrhage (SAH) accounts for 5% of all strokes and is associated with high morbidity and mortality. Rupture of intracranial aneurysm is the cause in 85% of cases. LÄS MER

5. 4. Targeted multiplex proteomics for risk stratification in patients with cardiovascular disease

   Författare :Emma Skau; Pär Hedberg; Jerzy Leppert; Johan Ärnlöv; Eva Swahn; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cardiovascular disease; proteomics; myocardial infarction; peripheral arterial disease; biomarker; GDF-15; Cardiology; Kardiologi;

   Sammanfattning : Risk stratification is valuable in patients with cardiovascular disease (CVD). Proteins involved in different pathophysiological processes in atherosclerosis have shown prognostic capacity. A new technology, Proximity Extension Assay (PEA), enables the simultaneous analysis of numerous plasma proteins from a minimal amount of plasma. LÄS MER