Sökning: "Proteasome genes"
Visar resultat 1 - 5 av 48 avhandlingar innehållade orden Proteasome genes.
1. The proteasome as a target for cancer therapy
Sammanfattning : The main objective of this PhD thesis was to evaluate the significance of proteasome genes as prognostic markers for different cancer types and identify specific cancer forms that respond to proteasome inhibition. The proteasome (PSM) plays an important role in maintaining cellular proteostasis and degrades the majority of proteins that require breakdown in the cell. LÄS MER
2. Investigating the activation and regulation of the proteasome : an essential proteolytic complex
Sammanfattning : The proteasome is a major non-lysosomal proteolytic complex present in eukaryotic cells and has a central role in regulating many protein levels. The complex has been shown to participate in various intracellular pathways including cell cycle regulation or quality control of newly synthesized proteins and many other key pathways. LÄS MER
3. The Path to Destruction : Understanding the mechanism and regulation of proteasomal degradation
Sammanfattning : A majority of intracellular proteins are degraded by the ubiquitin proteasome system (UPS). In this thesis, both the mechanism of the degradation and the regulation of UPS have been investigated. The importance of the p97 ATPase for proteasomal degradation of cytosolic substrates was examined. LÄS MER
4. Genetic and Molecular Studies of Two Hereditary Skin Disorders
Sammanfattning : Monogenic disorders, i.e., disorders caused by mutations in a single gene, are rare and clinically heterogeneous conditions. Identification of the genetic cause of monogenic traits can bring new insights into molecular pathways and disease mechanisms. LÄS MER
5. The interactome of the Epstein-Barr virus nuclear antigen 5 suggests novel roles in RNA and protein metabolism
Sammanfattning : Epstein-Barr virus (EBV) is a human herpes virus that infects B and epithelial cells of the oropharynx. EBV is transmitted by saliva and establishes a lifelong latency in over 90% of the world's population. During latency, the virus exists predominantly as multicopy episomes in the nuclei of memory B cells. LÄS MER