Sökning: "NLRP3 inflammasome"

Visar resultat 1 - 5 av 25 avhandlingar innehållade orden NLRP3 inflammasome.

  1. 1. Innate immunity in human atherosclerosis and myocardial infarction : Role of CARD8 and NLRP3

    Författare :Geena Paramel Varghese; Karin Fransén; Allan Sirsjö; Liza Ljungberg; Johan Frostegård; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Atherosclerosis; Inflammasome; NLRP3; CARD8; Myocardial infarction; Endothelial cells; Polymorphism; IL-1β; Cytokines; Innate immunity; Biomedicin; Biomedicine;

    Sammanfattning : Atherosclerosis is complex inflammatory disease of the arterial wall with progressive accumulation of lipids and narrowing of the vessel. Increasing evidence suggest that inflammation plays an important role in plaque stability and often accelerate cardiovascular events such as myocardial infarction (MI). LÄS MER

  3. 2. The role of caspase-1, caspase-4, NLRP3 and IL-1RA in bladder epithelial cells infected by uropathogenic Escherichia coli

    Författare :Anna Lindblad; Isak Demirel; Manisha Yadav; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Urinary tract infection; inflammasome; uropathogenic Escherichia coli; NLRP3; caspase-1; caspase-4; IL-1RA; antimicrobial peptides; estrogen;

    Sammanfattning : Urinary tract infection is one of the most common infections and is mostlycaused by uropathogenic Escherichia coli (UPEC). The inflammasomeassociatedproteins caspase-1, caspase-4 and NLRP3 are essential in the hostcell response during urinary tract infection by regulating IL-1β release. LÄS MER

  4. 3. Staphylococcus aureus bacteremia, molecular epidemiology and host immune response

    Författare :Gunlög Rasmussen; Bo Söderquist; Kristoffer Strålin; Eva Särndahl; Peter Bergman; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Staphylococcus aureus; molecular epidemiology; DNAmicroarray; bacteremia; sepsis; NLRP3; inflammasome; caspase-1; HLA-DR; HLA-DRA; CD74;

    Sammanfattning : Staphylococcus aureus is a major pathogen responsible for a considerable disease burden worldwide. It may cause a wide array of infections, from superficial skin infections to invasive bacteremia and complications such as infective endocarditis (IE) and osteomyelitis. This thesis aimed to investigate aspects of the molecular epidemiology of S. LÄS MER

  5. 4. Genetic Variations in the NLRP3 Inflammasome : Susceptibility Factor for Chronic Inflammation

    Författare :Deepti Verma; Peter Söderkvist; Särndahl Särndahl; Hal Hoffman; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : NLRP3 has been recognized as one of the key components of innate immunity. Upon activation, NLRP3 forms a multiprotein complex called as the ‘inflammasome’ which leads to the activation of pro-inflammatory caspase-1 which subsequently results in the formation of Interleukin (IL)-1β and IL-18. LÄS MER

  7. 5. Inflammasome polymorphisms and the Inflammatory Response to Bacterial Infections

    Författare :Berhane Asfaw Idosa; Eva Särndahl; Anne Kelly; Bo Söderquist; Alexander Persson; Johan Bylund; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bacteremia; Cytokines; Gene variants; Inflammasome; Inflammation; Innate immunity; Neutrophils; Meningitis; Neisseria meningitidis; Biomedicin; Biomedicine;

    Sammanfattning : NLRP3 inflammasome; a key component of the innate immune system, can be activated by a number of pathogens and other threats of the body. Activation of the NLRP3 inflammasome triggers caspase-1 mediated maturationof IL-1β and IL-18. LÄS MER