Sökning: "Munc-18"

Hittade 4 avhandlingar innehållade ordet Munc-18.

  1. 1. Exocytosis in Type 2 Diabetes- Functional and genetic studies of hormone secretion

    Författare :Sofia A Andersson; Diabetes - öcellsexocytos; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 Diabetes; Insulin; Glucagon; Alpha-cells; Beta-cells; Exocytosis; Capacitance; SNARE; SNAP25; Syntaxin1A; Synaptotagmin; Munc-18 Stxbp1 ; SNP; Expression; miRNA;

    Sammanfattning : Type 2 Diabetes (T2D) is characterized by dysregulated beta-and alpha-cell hormone secretion leading to elevated blood glucose levels. Several proteins are crucial in maintaining exocytosis of the hormone-containing granules such as Syntaxin1A (Stx1A), SNAP25, Munc-18 (Stxbp1) and the family of Synaptotagmins (Syts). LÄS MER

  3. 2. Proteins regulating vesicular docking and fusion : histochemical studies on their presence and regulation in endocrine, neuroendocrine and neuronal cells

    Författare :Gunilla Jacobsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :- axotomy; botulinum neurotoxin; cranial nerve; CSP; ECL; endocrine; estrogen; exocytosis; hypothalamus; immunohistochemistry; in situ hybridization; motoneuron; mouse; mRNA; munc-18; pancreas; parasympathetic; pituitary; rat; salt-loading; sciatic n;

    Sammanfattning : Regulated transmitter release involves docking and fusion of transmitter-containing vesicles with the plasma membrane. Vesicular docking and fusion events are mediated by specific exocytotic proteins located at the vesicle membrane, in the cytoplasm or at the plasma membrane. LÄS MER

  4. 3. Studies on proteins involved in the molecular regulation of insulin exocytosis

    Författare :Wei Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Actin; ADP; ATP; Ca2 channel; CAPS; beta-cells; CSP; exocytosis; GK rat; insulin; islet; Mint; Munc-18; NSF; PI 4-kinase; PI 4 P; PI 4; 5 P2; alpha-SNAP; SNAP-25; synaptotagmin III; syntaxin; tomosyn; type 2 diabetes mellitus; VAMP-2.;

    Sammanfattning : Type 2 diabetes mellitus is a disease characterized by impaired insulin secretion and insulin resistance. Better understanding of molecular mechanisms of insulin secretion may help to optimize type 2 diabetes management. LÄS MER

  5. 4. Architecture and function of the insulin granule secretion machinery

    Författare :Peng Yin; Sebastian Barg; Herbert Gaisano; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Docking; Syntaxin-1A; Voltage-gated Ca2 Channels; Exocytosis; Type-2 Diabetes;

    Sammanfattning : Insulin is released into the blood stream to normalize elevated blood glucose, for example after a meal. The hormone is synthesized by β-cells in the endocrine pancreas, and stored in small vesicles, known as secretory granules, until required. When glucose is elevated, these granules undergo regulated exocytosis and thereby secrete the hormone. LÄS MER