Sökning: "Lund University."

Visar resultat 1 - 5 av 8795 avhandlingar innehållade orden Lund University..

  1. 1. Chemogenetics, Induced Neurons and Pluripotent Stem Cells: Towards Advanced Gene and Cell Therapies Targeting Epilepsy

    Detta är en avhandling från Department of Clinical Sciences, Lund University

    Författare :Natalia Avaliani; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2015]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; iPS; Chemogenetics; iN; electrophysiology; gene and cell therapy; Epilepsy;

    Sammanfattning : The complexity of the central nervous system and existence of the blood-brain barrier often causes difficulties for traditional pharmacological treatments of neurological diseases. This thesis explores the feasibility and potential for novel gene and cell therapy approaches, which hold better promise for neurological disorders, while particularly targeting epilepsy. LÄS MER

  2. 2. Factors Regulating Neurogenesis in Intact and Pathological Brain: Role of TNF-alpha

    Detta är en avhandling från Department of Clinical Sciences, Lund University

    Författare :Robert Iosif; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2008]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : During the last decade it has been clearly demonstrated that the adult brain contains neural stem cells (NSCs) localized mainly in two regions: the subgranular zone in the dentate gyrus and the subventricular zone (SVZ) lining the lateral ventricles. In the intact brain, these NSCs give rise to new dentate granule cells and olfactory bulb neurons, respectively. LÄS MER

  3. 3. Studies on cellular changes and amnesia in a rat model of electroconvulsive therapy

    Detta är en avhandling från Molecular Psychiatry Unit

    Författare :Linda Jansson; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiogenesis; electroconvulsive seizures; glial cell activation; amnesia; lithium;

    Sammanfattning : Electroconvulsive therapy (ECT) is a well-established treatment for severe depressive disorder, but its clinical use has been limited by concerns about side effects such as memory disturbances. Despite over 70 years in clinical use, the exact mechanisms of action behind the therapeutic or adverse effects are not fully understood. LÄS MER

  4. 4. Neural Stem Cells - interaction with the brain and prospects for cell replacement therapy for Stroke

    Detta är en avhandling från Neural stem cell biology and therapy

    Författare :Emanuela Monni; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2015]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human; Neural stem cells; fetus; cortex; striatum; stroke; transplantation; inflammation; fusion; reprogramming; chimera; heterokaryon;

    Sammanfattning : Stroke is an acute neurological condition and the leading cause of disability in adult humans. Treatments for efficient recovery are not available. The most common form of stroke results from the occlusion of the middle cerebral artery, which causes loss of brain parenchyma and many types of neurons as well as astrocytes and oligodendrocytes. LÄS MER

  5. 5. Novel approaches to explore mechanisms of epileptic seizures - optogenetic and chemogenetic manipulation of hippocampal circuitry

    Detta är en avhandling från Experimental Epilepsy Group

    Författare :Fredrik Berglind; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epileptogenesis; Seizure; optogenetics; NpHR; ChR2; DREADD; hippocampus; in vivo; mouse;

    Sammanfattning : Epilepsy comprises a family of neurological disorders characterized by recurrent seizures, which can be highly debilitating. Up to 30% of patients with temporal lobe epilepsy, the most common form of the disorder in adults, arising in the hippocampus, cannot be effectively treated by current pharmaceuticals. LÄS MER