Sökning: "Lovisa Lundholm"

Hittade 4 avhandlingar innehållade orden Lovisa Lundholm.

  1. 1. Molecular mechanisms of estrogen action in relation to metabolic disease

    Författare :Lovisa Lundholm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Estrogens have multiple effects on the body. Most studied are the effects on female reproduction. In this thesis, we have focused on the metabolic effects of estrogens. Estrogen treatment decreases adipose tissue mass and has anti-diabetic effects in humans and mice. LÄS MER

  3. 2. Factors modifying cellular response to ionizing radiation

    Författare :Lei Cheng; Andrzej Wojcik; Siamak Haghdoost; Lovisa Lundholm; Penelope A. Jeggo; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Radiation biology; DNA damage; gene expression; alpha particles; X-rays; mixed beams; gamma rays; hypothermia; dose rate.; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Many physical factors influence the biological effect of exposure to ionizing radiation, including radiation quality, dose rate and temperature. This thesis focuses on how these factors influence the outcome of exposure and the mechanisms behind the cellular response. LÄS MER

  4. 3. Cellular effects of ionizing radiation : Relevant for understanding cancer risk after medical and environmental radiation exposures

    Författare :Pamela Chiaka Akuwudike; Andrzej Wojcik; Lovisa Lundholm; Kerstin Borgmann; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiation; DNA damage; radiation-induced carcinogenesis; second primary cancer; cisplatin chemoradiotherapy; dose fractionation; low dose; low dose rate; dose and dose rate effectiveness factor DDREF ; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Radiation-induced cancers are stochastic and delayed effects of exposure to ionizing radiation. The dose-response relationship for radiation-induced cancers at both low dose/low dose rates and high doses (doses encountered during radiotherapy) remains unclear. LÄS MER

  5. 4. Biomarkers of ionising radiation relevant to carcinogenesis : Dose, dose rate and LET dependency of the responses

    Författare :Milagrosa López Riego; Andrzej Wojcik; Lovisa Lundholm; Alexandros G. Georgakilas; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ionising radiation; low dose; low dose rate; linear energy transfer LET ; mixed beams; dose and dose rate effectiveness factor DDREF ; cancer; DNA damage response; biomarkers; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : A better understanding of the relationship between ionising radiation (IR) dose, dose rate and radiation quality, and the risk of stochastic effects would improve risk extrapolation from atomic bomb survivors’ data. Owing to insufficient statistical power of epidemiological studies to detect excess incidence of cancer following low doses of IR delivered at low dose rates (LDLDR), as typically encountered in most common human exposure scenarios, radiobiological experiments are fundamental to describe the biological effectiveness of LDLDR and to define the underlying molecular mechanisms. LÄS MER