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Visar resultat 1 - 5 av 37 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Time-Resolved Attosecond Spectroscopy of He Using COLTRIMS

   Författare :Predrag Ranitovic; Reinhold Schuch; C. L. Cocke; Robert Moshammer; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; attosecond spectroscopy; Physics; Fysik; Physics; fysik;

   Sammanfattning : Tunable ultrafast lasers are becoming a standard tool for probing and controlling the dynamics of atoms, molecules and chemical reactions. This thesis is a contribution to a large, ongoing effort to make spectroscopic tools for inducing and controlling, in real time, the natural processes which occur on the femto and attosecond times scales. LÄS MER

3. 2. Bridging the gap between lipid dyshomeostasis and brain disorders : role of prosaposin and progranulin

   Författare :Yachao He; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Brain tissue is the second-highest lipid-containing tissue after adipose in the human body. Lipid homeostasis maintenance requires the coordination of multiple cellular organelles. Pathogenesis of brain disorders, especially Parkinson’s disease (PD), usually involves different dysfunctional pathways that intimately link to lipid homeostasis. LÄS MER

4. 3. Student modelling based on collaborative dialogue with a learning companion

   Författare :Eva L. Ragnemalm; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Computer science; Datavetenskap;

   Sammanfattning : When using computers to support learning, one significant problem is how to fmd out what the student understands and knows with respect to the knowledge the computer system is designed to help him to learn (the system's content goal). This analysis of the student is based on the input he provides to the system and it is evaluated with respect to the content goals of the system. LÄS MER

5. 4. SACRED or NEURAL? : Neuroscientific Explanations of Religious Experience: A Philosophical Evaluation

   Författare :Anne L. C. Runehov; Mikael Stenmark; J. Wentzel van Huyssteen; Uppsala universitet; []
   Nyckelord :HUMANIORA; HUMANITIES; Philosophy of religion; Neuroscience; Neurotheology; Persinger; d Aquili; Newberg; neuroimaging technology; epilepsy; meditation; explanatory models; reductionism; religious experience; science and theology; Religionsfilosofi; Philosophy of religion; Religionsfilosofi; Philosophy of Religion; religionsfilosofi;

   Sammanfattning : Neuroscientists place different explanations at our disposal of what religious experiences are. Some neuroscientists explain religious experiences in terms of consequences of a damaged, malfunctioning or mentally deranged brain. Others explain them in terms of existential crises. LÄS MER

7. 5. Conformationally Constrained Oligonucleotides for RNA Targeting

   Författare :Qing Li; Jyoti Chattopadhyaya; Li-He Zhang; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; conformationally constrained nucleoside; antisense oligonucleotide; RNA affinity; nuclease stability; RNase H; RNA degradation; Chemistry with specialization in Bioorganic Chemistry; Kemi med inriktning mot bioorganisk kemi;

   Sammanfattning : A short oligonucleotide sequence as in a single-stranded antisense oligo nucleotides (AON) or in double-stranded small interfering RNAs (siRNA) can modulate the gene expression by targeting against the cellular mRNA, which can be potentially exploited for therapeutic purposes in the treatment of different diseases. In order to improve the efficacy of oligonucleotide-based drugs, the problem of target affinity, nuclease stability and delivery needs to be addressed. LÄS MER