Sökning: "Intestinal perfusion"
Visar resultat 1 - 5 av 38 avhandlingar innehållade orden Intestinal perfusion.
1. Exploring Intestinal Ischemia : An experimental study
Sammanfattning : Background and aims: Unrecognized intestinal mucosal ischemia in severely ill patients may trigger development of multiple organ failure. Such ischemia can be evaluated by intraluminal tonometry reflecting mucosal PCO2 and intramucosal pH (pHi). LÄS MER
2. Membrane transport and the human small intestine : Relation to mucosal protection, intestinal anaphylaxis and nitric oxide
Sammanfattning : The tightly adherent monolayer of epithelial cells that line the luminal side of the intestine provides a dynamic and highly regulated barrier to the passive and active transport of ions, water and macromolecules. Cathecol-O-methyl transferase inhibition prevents tissue degradation of catecholaminesincluding dopamine and intracellular carbonic anhydrase activity is an important regulator of ion and water transport in the small intestine. LÄS MER
3. Vasopressors and intestinal mucosal perfusion
Sammanfattning : .... LÄS MER
4. Intestinal preservation for transplantation: translational approaches
Sammanfattning : Background: Intestinal preservation injury (IPI) may result in various degrees of mucosal damage, which may later favor bacterial translocation, post-reperfusion syndrome, and upregulation of alloreactivity. Experimental evidence suggests that combining vascular perfusion and cold storage with luminal interventions using polyethylene glycol (PEG) solutions may mitigate the mucosal damage and extend the safe storage time. LÄS MER
5. Intestinal absorption of drugs : The impact of regional permeability, nanoparticles, and absorption-modifying excipients
Sammanfattning : For successful delivery of orally given drug products, the drug compounds must have adequate solubility and permeability in the human gastrointestinal tract. The permeability of a compound is determined by its size and lipophilicity, and is usually evaluated in various pre-clinical models, including rat models. LÄS MER