Sökning: "intestinal ischemia"

Visar resultat 1 - 5 av 30 avhandlingar innehållade orden intestinal ischemia.

  1. 1. Exploring Intestinal Ischemia : An experimental study

    Författare :Rolf Fröjse; Conny Arnerlöv; Ola Winsö; Stefan Lehtipalo; Eric Wahlberg; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; gastrointestinal tonometry; continuous; pig; pHi; intestinal ischemia; intestinal vascular bed; lactate; tissue oxygen tension; microdialysis; dopexamine; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Sammanfattning : Background and aims: Unrecognized intestinal mucosal ischemia in severely ill patients may trigger development of multiple organ failure. Such ischemia can be evaluated by intraluminal tonometry reflecting mucosal PCO2 and intramucosal pH (pHi). LÄS MER

  3. 2. Pulmonary Injury Following Intestinal Ischemia and Reperfusion in Rats

    Författare :Anna Börjesson; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reperfusion injury; intestinal ischemia; pulmonary injury; endothelium; cytokines; alveolar fluid clearance; leukocytes; orthopaedics; Surgery; traumatology; ortopedi; Kirurgi; traumatologi;

    Sammanfattning : Intestinal ischemia and reperfusion (I/R) is a potentially life-threatening condition, sometimes leading to a systemic inflammatory response and the potential development of the multiple organ dysfunction syndrome. The overall aim of the thesis was to study the effects of intestinal I/R on pulmonary function with special emphasis on removal of excess alveolar fluid, pulmonary endothelial barrier permeability, leukocyte accumulation and function, and possible therapeutic strategies to prevent the development of pulmonary injury following intestinal I/R. LÄS MER

  4. 3. Intestinal ischemia and reperfusion. Proinflammatory response and organ dysfunction

    Författare :Knut Olanders; Lund Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; traumatology; Kirurgi; ortopedi; traumatologi; orthopaedics; Surgery; inflammation; cytokine; leukocyte; reperfusion; ischemia; permeability; Intestine; endothelium;

    Sammanfattning : Intestinal I/R is considered to be an important initiating event in several pathophysiological conditions such as trauma, bleeding, sepsis and pancreatitis, frequently leading to concomitant both single and potentially multiple organ dysfunction. The purpose of this thesis was to study mechanims underlying the development of multiple organ dysfunction, with special focus on intercellular proinflammatory regulation in the concurrent development of tissue injury. LÄS MER

  5. 4. Intestinal effects of lung recruitment maneuvers

    Författare :Jonas Claesson; Ola Winsö; Stefan Lehtipalo; Conny Arnerlöv; Björn Biber; Göran Hedenstierna; Petter Aadahl; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute lung injury; oleic acid lung injury; ischemia; reperfusion injury; swine; mechanical ventilation; lung recruitment; splanchnic circulation; laser Doppler flowmetry; tissue oxygen tension; microdialysis; lactate; glycerol; Anaesthetics and intensive care; Anestesiologi och intensivvård; lungmedicin; Lung Medicine;

    Sammanfattning : Background and aims: Lung recruitment maneuvers (brief episodes of high airway pressure) are a modern treatment alternative to achieve open lung conditions under mechanical ventilation of patients with acute lung injury. It is well known that positive pressure ventilation with high airway pressures cause negative circulatory effects, and that the effects on regional vascular beds can be even more pronounced than the systemic effects. LÄS MER

  7. 5. Intestinal preservation for transplantation: translational approaches

    Författare :John M. Söfteland; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intestinal transplantation; intestinal preservation; apoptosis; tight junction; luminal preservation;

    Sammanfattning : Background: Intestinal preservation injury (IPI) may result in various degrees of mucosal damage, which may later favor bacterial translocation, post-reperfusion syndrome, and upregulation of alloreactivity. Experimental evidence suggests that combining vascular perfusion and cold storage with luminal interventions using polyethylene glycol (PEG) solutions may mitigate the mucosal damage and extend the safe storage time. LÄS MER