Sökning: "Intestinal immunity"

Visar resultat 1 - 5 av 64 avhandlingar innehållade orden Intestinal immunity.

  1. 1. Intestinal Mucosa Reconstitution and Protection: Impact of Luminal Factors

    Författare :Yilei Mao; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Probiotics; Pectin; Oat; Methotrexate; Lactobacilli; Intestinal injury; Intestinal immunity; Intestinal barrier; Enterocolitis; Fiber; Radiation; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

    Sammanfattning : The gastrointestinal mucosa is one of the most rapidly proliferating tissues in the body, and serves as a barrier to luminal bacteria and toxins. Enteral nutrition, luminal fiber and probiotics are of crucial importance for the integrity of this barrier. LÄS MER

  3. 2. Macrophages in Crohn's Disease: lnnate immune cellular and molecular mechanisms driving intestinal inflammation and fibrosis

    Författare :Frida Gorreja; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; macrophages; inflammatory macrophages; tissue-resident macrophages; efferocytosis; innate immunity; myeloid cells; fibroblasts; fibrosis; inflammasomes; Crohn´s disease; inflammatory bowel diseases; digestive diseases; mucosa immunology; intestinal immunity; intestinal inflammation; serum systemic inflammation; microbiota; metabolites;

    Sammanfattning : Macrophages and their interactions with the lamina propria and luminal microenvi-ronment are crucial in the pathogenesis of Crohn´s disease (CD), a chronic inflamma-tory disease with a strong inflammatory innate immune involvement. Therefore, in-terpreting macrophage activity in the intestinal microenvironment may identify treatment targets beneficial for at least a subgroup of patients. LÄS MER

  4. 3. The ontogeny and function of intestinal dendritic cells

    Författare :Emma Persson; Slemhinnans immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mesenteric lymph nodes; Intestine; Dendritic cells; Gut-homing; Th17 cells; Oral tolerance; Immunity;

    Sammanfattning : The intestinal mucosa presents a huge surface area to the external environment and the intestinal immune system is continually exposed to a wide array of foreign antigens derived from resident intestinal microbiota as well as dietary constituents, including food proteins. In order to maintain intestinal homeostasis, the intestinal immune system relies on the ability to generate tolerogenic responses to innocuous antigen while maintaining the ability to develop effective immune responses to intesinal pathogens. LÄS MER

  5. 4. Human intestinal T lymphocytes : a comparative analysis of phenotype and function in normal and inflamed mucosa

    Författare :Silvia Melgar; Nadine Cerf-Bensussan; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human intestinal mucosa; intraepithelial lymphocyte; lamina propria lymphocyte; γδ T cell; regulatory T cell; cytotoxicity; cytokine; basal lymphoid aggregate; ulcerative colitis; Crohn s disease;

    Sammanfattning : The epithelial lining of the gut must allow immediate contact with beneficial components as nutrients and normal microflora. At the same time it runs the constant risk of attack from pathogenic microbes and noxious agents. LÄS MER

  7. 5. Natural killer T (NKT) lymphocytes regulate of intestinal tumor immunity

    Författare :Ying Wang; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NKT lymphocyte; intestinal tumor; CD1d; colrectal cancer; immunoregulation; α-gagactosylceramide;

    Sammanfattning : CD1d-restricted natural killer T (NKT) lymphocytes are known as potent early regulatory cells of immune responses, acting as a bridge between innate and adaptive immunity. While invariant NKT (iNKT) cells have a protective role in many tumor models, their ability to promote intestinal inflammation, known to enhance intestinal cancer, raised the question if they would be protective in intestinal tumor development. LÄS MER