Sökning: "IGFBP-4"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet IGFBP-4.

  1. 1. Growth Hormone in Athletes

    Författare :Christer Ehrnborg; Göteborgs universitet; []
    Nyckelord :Growth hormone; IGF-I; bone markers; doping; athletes; maximum exercise test; variability; supraphysiological; body composition; physical performance; IGFBP-4; IGFBP-5;

    Sammanfattning : Doping with growth hormone (GH) is a well-known problem both among elite athletes and among people training at gyms. It is mainly the anabolic and, to some extent, lipolytic effect of GH that is valued by its users. LÄS MER

  3. 2. Smooth muscle hypertrophy and the IGF-system

    Författare :Yun Chen; David R. Clemmons; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Insulin-like growth factor-! (IGF-I) has both metabolic and mitogenic effects on smooth muscle cells (SMCs). The effects of IGF-I are modified by a group of binding proteins (IGFBPs). The present study was devoted to smooth muscle hypertrophy and the IGF-system in smooth muscle under different conditions. LÄS MER

  4. 3. Human insulin-like growth factor binding protein-4 and -6 : gene structure and transcription regulation

    Författare :Henric Zazzi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :IGF binding proteins IGFBP ; DNA sequencing; chromosomal localization; gene expression; Sp I; NF-kappa-B; methylation;

    Sammanfattning : Insulin-like growth factors (IGF-I and IGF-II) are among the more abundant growth factors isolated from bone tissue and are synthesized by various bone cells including osteoblasts. The activity of IGFs is controlled by a family of binding proteins (IGFBPs) divided into subfamilies depending on their individual affinity for IGFs. LÄS MER

  5. 4. Parathyroid hormone-related protein (PTHrP), calcium and human osteoblast-like cells

    Författare :Jon A Tsai; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :hOB cells; PTHrP; cAMP; IGFs; IGFBPs; IL-1ß; TGF-ß; [Ca 2 ]i; [Ca2 ]O;

    Sammanfattning : Parathyroid hormone-related protein (PTHrP) may cause humoral hypercalcernia of malignancy (HHM) when overproduced by malignant tumors, but is also produced in lower amounts under normophysiological conditions in practically all cell types, including osteoblasts. One of the aims of the present study was to investigate interactions between PTHrP and osteoblasts, to elucidate bone-regulating functions of PTHrP. LÄS MER

  7. 5. Regulation and actions of insulin-like growth factor binding proteins in vascular smooth muscle cells

    Författare :Thomas Gustafsson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Insulin-like growth factor-I (IGF-I) has multiple actions on vascular smooth muscle cell (VSMCs) function. In the circulation and in extracellular fluids, IGF-I is complexed to high affinity IGF-binding proteins (IGFBPs), which modulate IGF-I bioactivity. The present study focused on expression and regulation of IGFBPs in VSMCs. LÄS MER