Sökning: "IGFBP-5"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet IGFBP-5.

  1. 1. Growth Hormone in Athletes

    Författare :Christer Ehrnborg; Göteborgs universitet; []
    Nyckelord :Growth hormone; IGF-I; bone markers; doping; athletes; maximum exercise test; variability; supraphysiological; body composition; physical performance; IGFBP-4; IGFBP-5;

    Sammanfattning : Doping with growth hormone (GH) is a well-known problem both among elite athletes and among people training at gyms. It is mainly the anabolic and, to some extent, lipolytic effect of GH that is valued by its users. LÄS MER

  3. 2. Parathyroid hormone-related protein (PTHrP), calcium and human osteoblast-like cells

    Författare :Jon A Tsai; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :hOB cells; PTHrP; cAMP; IGFs; IGFBPs; IL-1ß; TGF-ß; [Ca 2 ]i; [Ca2 ]O;

    Sammanfattning : Parathyroid hormone-related protein (PTHrP) may cause humoral hypercalcernia of malignancy (HHM) when overproduced by malignant tumors, but is also produced in lower amounts under normophysiological conditions in practically all cell types, including osteoblasts. One of the aims of the present study was to investigate interactions between PTHrP and osteoblasts, to elucidate bone-regulating functions of PTHrP. LÄS MER

  4. 3. Bone disease and diabetes mellitus

    Författare :Anna Ugarph-Morawski; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Diabetes Mellitus (DM) and Osteoporosis (OP) frequently co-exist with advanced age and imply large health challenges worldwide. The last decades there has been a growing interest regarding fracture risk in DM. Currently used screening methods (Dual Energy X-ray Absorptiometry (DXA) and FRAX) underestimate fracture risk in diabetes patients. LÄS MER

  5. 4. Spinal motoneurons and molecules related to neurotrophic function after axon injury

    Författare :Henrik Hammarberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :immunohistochemistry; in situ hybridization; spinal cord; motoneuron; axotomy; survival; regeneration; MHC 1; leukocyte; cell culture; mRNA expression;

    Sammanfattning : The capacity of motoneurons to survive and regenerate new axons after injuries such as axotomy depends on a great variety of parameters. After sciatic nerve transection (SNT) in adult rats and to some extent after a ventral funiculus lesion (VFL), many cells survive and regeneration is highly prioritized. LÄS MER

  7. 5. Regulation and actions of insulin-like growth factor binding proteins in vascular smooth muscle cells

    Författare :Thomas Gustafsson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Insulin-like growth factor-I (IGF-I) has multiple actions on vascular smooth muscle cell (VSMCs) function. In the circulation and in extracellular fluids, IGF-I is complexed to high affinity IGF-binding proteins (IGFBPs), which modulate IGF-I bioactivity. The present study focused on expression and regulation of IGFBPs in VSMCs. LÄS MER