Sökning: "Helena Öberg"
Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Helena Öberg.
1. Diatoms in Lake Duluti : Tracking Environmental Variability in Northern Tanzania during the Past 1000 Years
Sammanfattning : The tropics are the regions which are least understood climatically and new data on past climate variability is necessary for reliable future modeling of climate change. This thesis contributes with new paleoenvironmental information from a small crater lake in northern Tanzania and provides an additional link between the integrated history of climate, environment and socioeconomic variability in tropical Africa. LÄS MER
2. Den svenska förvaltningsmodellen : Parlamentarisk debatt om förvaltningens roll i styrelseskicket
Sammanfattning : The aim of the thesis is to describe and critically examine the parliamentary debate on the role of administrative agencies in Sweden during the period 1975–2000. What views on delegation, administrative discretion and steering tools are advocated by the Swedish political parties? Which is the proper role of administrative agencies in a democracy? The author suggests that agencies might be perceived as obedient tools or as counter powers. LÄS MER
3. Targeted Inhibition of Polycomb Repressive Complexes in Multiple Myeloma : Implications for Biology and Therapy
Sammanfattning : Multiple myeloma (MM) is a hematological malignancy of antibody producing plasmablasts/plasma cells. MM is characterized by extensive genetic and clonal heterogeneity, which have hampered the attempts to identify a common underlying mechanism for disease establishment and development of appropriate treatment regimes. LÄS MER
4. Epigenetic gene regulation in multiple myeloma and mood disorders
Sammanfattning : Epigenetics continues to be redefined and new discoveries are likely to revolutionise the field still further. This thesis explores different aspects of how epigenetic regulation of gene expression contributes to human disease. LÄS MER
5. Targeting molecular mechanisms for epigenetic silencing in multiple myeloma : Implications for biology and precision medicine
Sammanfattning : Multiple myeloma (MM) is a heterogeneous haematological cancer where malignant plasma cells clonally expand within the bone marrow. The transcriptional repressor PRC2 and its catalytic subunit EZH2 play a major role in MM, as PRC2 re-targeting results in a MM-specific gene silencing profile. LÄS MER
