Sökning: "Hanzhao Zhang"

Hittade 1 avhandling innehållade orden Hanzhao Zhang.

  1. 1. Role of MYCN in retinoblastoma : From carcinogenesis to tumor progression

    Författare :Hanzhao Zhang; Finn Hallböök; Johan Holmberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MYCN; retinoblastoma; RNA sequencing; cancer; avian; E2F; carcinogenesis; Developmental Neurosciences; Medicinsk utvecklings- och neurobiologi;

    Sammanfattning : Retinoblastoma, a pediatric malignancy of the retina, is primarily driven by the bi-allelic inactivation of the RB1gene. However, a subset of cases are characterized by proficient RB1 functions but with MYCN copy number mutations, suggesting an alternative oncogenic mechanism in the absence of RB1 mutations. LÄS MER