Sökning: "FARMACI Farmakognosi"

Visar resultat 11 - 15 av 47 avhandlingar innehållade orden FARMACI Farmakognosi.

  1. 11. Statistics on local drug sales: A tool to identify problem areas and to follow effects of education on drug use

    Författare :Anders Ekedahl; Kardiovaskulär forskning - epidemiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; unused drugs; Pharmacological sciences; toxikologi; farmaci; farmakognosi; Farmakologi; toxicology; pharmacognosy; pharmacy; producer independent information; drug sales statistics;

    Sammanfattning : Aims: 1) To assess if drug sales data indicate differences in morbidity, mortality, socio-economic conditions and deviating prescribing habits among physicians; 2) to identify areas for educational interventions and to analyse changes in prescribing after educational activities. In addition, an effort was made to estimate differences between pharmacy sales and purchases by the population, and the amount and value of unused drugs returned to pharmacies. LÄS MER

  3. 12. Pharmacokinetics of the enantiomers of thalidomide

    Författare :Tommy Eriksson; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein binding; blood distribution; stereoselective pharamacokinetics; pharmacokinetic modelling; oral administration; intravenous administration; chiral inversion; stereospecific assay; HPLC; Thalidomide; hydroxylated metabolites; enantiomers; in vitro kinetics; sedative effects; concentration-effect relationship.; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Sammanfattning : Thalidomide has a chiral center and the racemate of (+)-(R) and (-)-(S)-thalidomide was introduced as a hypnotic/sedative drug in 1957. In 1961 it was withdrawn due to teratogenicity and neuropathy. There is a growing interest in thalidomide treatment of immunomodulatory diseases. LÄS MER

  4. 13. Interaction between Calcium, Calciotropic Hormones and the Gastrin-ECL-cell Axis

    Författare :Rebecca Gagnemo Persson; Hälsofrämjande komplexa interventioner; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacognosy; Pharmacological sciences; rat; chicken; parathyroid gland; stomach; vitamin D; PTH; CT; calciotropic hormones; Gastrin; calcium; ECL cell; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi; Histology; cytochemistry; histochemistry; tissue culture; Histologi; cytokemi; histokemi; vävnadskultur;

    Sammanfattning : Calcium homeostasis involves mainly the interaction of PTH, vitamin D and CT. The stomach may be important for calcium homeostasis. Gastric acid is thought to mobilize calcium from the diet, thereby facilitating the absorption of calcium in the small intestines. LÄS MER

  5. 14. Molecular targets for glucocorticoids in macrophages: cytosolic phospholipase A2 and cytokine formation

    Författare :Karin Gewert; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacognosy; Pharmacological sciences; signal transduction; dexamethasone; cytosolic phospholipase A2; glucocorticoids; macrophages; protein kinase C; mitogen-activated protein kinases; TNF-alpha; IL-1beta; protein phosphatases; okadaic acid; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Sammanfattning : The aim of this investigation has been to study mechanisms by which glucocorticoids inhibit inflammatory processes in vitro. Type IV cytosolic 85 kDa phospholipase A2 (cPLA2) is an important modulator of inflammatory responses that is present in macrophages as well as in other cell types. LÄS MER

  7. 15. On receptor changes in cerebral arteries after subarachnoid haemorrhage

    Författare :Jacob Hansen-Schwartz; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi; Pharmacological sciences; subarachnoid haemorrhage; reverse transcriptase polymerase chain reaction; in vitro pharmacology; organ culture; Endothelin receptors; 5-HT receptors;

    Sammanfattning : Overall the aim has been to characterise the in vitro upregulation of the 5-hydroxytryptamine 1B/1D (5-HT(1B/1D)) and endothelin (ET) receptors in the cerebral circulation as well as demonstrating phenotypic changes in a pathophysiological model mimicking subarachnoid haemorrhage. The first part describes receptor upregulation using organ culture of whole vessel segments from both rat and man. LÄS MER