Sökning: "Eicosanoid"

Visar resultat 16 - 20 av 38 avhandlingar innehållade ordet Eicosanoid.

  1. 16. Structural biology of integral membrane proteins - From methods to molecular mechanisms

    Författare :Damian Niegowski; Pär Nordlund; Richard Neutze; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; membrane proteins; CorA; magnesium transport; screening; Leukotriene C4 synthase; detergents; Biochemistry; Biokemi; Biochemistry; biokemi;

    Sammanfattning : Membrane proteins are vital components in the cell and crucial for the proliferation of all living organisms. Unfortunately our collective knowledge of structures of membrane proteins is very limited, as compared to the information available on soluble proteins. LÄS MER

  3. 17. Signal transduction in macrophages. Intracellular pathways activated by microbial constituents

    Författare :Sandra Olsson; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; TNF; TLR; dectin-1; lipid rafts; Src; Btk; Macrophages; arachidonate;

    Sammanfattning : Macrophages play an essential role in the defense against infection by phagocytosis and by production of inflammatory mediators. Such mediators are TNF? and eicosanoids. Many microbial agents elicit arachidonate release in macrophages that lead to the formation of eicosanoids. LÄS MER

  4. 18. Eicosanoids and exosomes : a link between macrophages and lung cancer

    Författare :Ana Lukic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic inflammation increases the risk of lung cancer. Macrophages (MO) are important players in inflammation, with regulatory and executive functions. Eicosanoids and exosomes can be both triggers and mediators of these functions. LÄS MER

  5. 19. Studies on expression and regulation of phospholipase A2 and cyclooxygenase 2 in gastrointestinal tissues with special reference to colorectal cancer

    Författare :Jan Dimberg; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The phospholipases A2 (PLA2s) are phospholipid hydrolyzing enzymes that in mammalian cells exist in several different isoform including cytosolic PLA2 (cPLA2), group I PLA2 (PLA2-I) and group II PLA2 (PLA2-ll). PLA2 is involved in production of inflammatory mediators, membrane remodelling, digestive functions and stimulation of prolifemtion. LÄS MER

  7. 20. Leukotriene C4 synthase : studies on oligomerization and subcellular localization

    Författare :Jesper Svartz; Mats Söderström; Sven Hammarström; Colin Funk; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Leukotrienes (LTs) are polyunsaturated fatty acid derivatives formed by oxygenation of arachidonic acid via the 5-lipoxygenase (5-LO) pathway. Upon activation of inflammatory cells 5-LO is translocated to the nuclear envelope where it converts arachidonic acid to the unstable epoxide LTA4. LÄS MER