Sökning: "Eicosanoid"
Visar resultat 6 - 10 av 38 avhandlingar innehållade ordet Eicosanoid.
6. Studies on a novel cytosolic/nuclear binding protein for the eicosanoid 12(S)-hydroxyeicosatetraenoic acid
Sammanfattning : Hydroxyeicosatetraenoic acids (HETEs) are lipoxygenase metabolites of arachidonic acid. HETEs were long considered to have few or no important biological function - a view that proved to be incorrect. LÄS MER
7. Mast cell activation in response to osmotic and immunological stimulation with focus on release of eicosanoid mediators
Sammanfattning : Mast cells are important in asthma and other inflammatory diseases. Subjects with asthma have been found to have an increased number of mast cells in their airway smooth muscle and this was related to airway sensitivity. LÄS MER
8. Quantification of inflammatory mediators to explore molecular mechanisms and sub-phenotypes of asthma
Sammanfattning : This thesis summarizes a series of studies using liquid chromatography coupled to mass spectrometry methodologies to quantify metabolites of fatty acids (i.e. LÄS MER
9. Antimicrobial peptides and eicosanoids : roles and interactions in inflammation and host defense
Sammanfattning : Antimicrobial peptides (AMPs) have a broad spectrum of activities and exert their functions by both direct killing of microbes through the interaction with the microbial membrane, and modulation of innate and adaptive immunity of the host. In humans, cathelicidins and defensins represent the major families of AMPs. LÄS MER
10. Identification of natural activators of the nuclear receptor peroxisome proliferator-activated receptor : relevance to the pathogenesis of atherosclerosis
Sammanfattning : Polyunsaturated fatty acids induce peroxisome proliferation. This phenomenon is mediated by the ligand-dependent transcription factor peroxisome proliferator-activated receptor (PPAR). This thesis is an investigation on the role of eicosanoids and oxidized products of linoleic acid for the activation of PPARs. LÄS MER
