Sökning: "Dmrt3"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet Dmrt3.

  1. 1. Deciphering the Locomotor Network : The Role of Spinal Cord Interneurons

    Författare :Sharn Perry; Klas Kullander; Kimberly Dougherty; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Locomotion; central pattern generator; mouse; gait; recurrent inhibition; Renshaw cell; Dmrt3; Chrna2; Neuroscience; Neurovetenskap;

    Sammanfattning : In the spinal cord, an intricate neural network generates and coordinates the patterning of limb movements during locomotion. This network, known as the locomotor central pattern generator (CPG), comprises of various cell populations that together orchestrate the output of motor neurons. LÄS MER

  3. 2. Neuronal Networks of Movement : Slc10a4 as a Modulator & Dmrt3 as a Gait-keeper

    Författare :Martin Larhammar; Klas Kullander; Leif Andersson; Åsa Wallén-Mackenzie; Robert Fyffe; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Synaptic vesicle transporter; Neuromodulation; Dopamine; Central Pattern Generator; Locomotion; Gait; Horse; Mouse; Commissural Inhibitory Interneuron; Neuroscience; Neurovetenskap;

    Sammanfattning : Nerve cells are organized into complex networks that comprise the building blocks of our nervous system. Neurons communicate by transmitting messenger molecules released from synaptic vesicles. Alterations in neuronal circuitry and synaptic signaling contribute to a wide range of neurological conditions, often with consequences for movement. LÄS MER

  4. 3. Swimming with the current : Fictive locomotion reveals subtle phenotypes in the zebrafish locomotor network

    Författare :Harmen Kornelis Koning; Henrik Boije; David McLean; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; dmrt3a; wt1a; spinal cord; Mauthner cell; neural development; locomotor network; zebrafish;

    Sammanfattning : Neural networks are the functional building blocks of the central nervous system. To better understand how these networks develop and operate, we turned to the zebrafish locomotor network, with a focus on subtypes of interneurons expressing dmrt3a and wt1a. LÄS MER

  5. 4. Functional Imaging of Spinal Locomotor Networks

    Författare :Chetan Nagaraja; Klas Kullander; Gilad Silberberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Central pattern generators; two-photon microscopy; locomotor rhythm; multiple rhythmicities; inhibitory neurotransmission; Neuroscience; Neurovetenskap;

    Sammanfattning : Movement is necessary for the survival of most animals. The spinal cord contains neuronal networks that are capable of motor coordination and of producing different movements. In particular, a very reduced neuronal network in the spinal cord can produce simple rhythmic outputs even in the absence of descending or sensory inputs. LÄS MER

  7. 5. Equine trait mapping : from disease loci to the discovery of a major gene controlling vertebrate locomotion

    Författare :Lisa Andersson; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : Assigning function to genes is essential for a better understanding of biological systems. To date, approximately half of the genes in the vertebrate genome have known function. Domestic animals are a rich source for trait mapping and in this thesis we have mapped three distinct equine phenotypes. LÄS MER