Sökning: "D-amphetamine"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet D-amphetamine.

  1. 1. Novel mechanism of action of antipsychotic drugs : effects on neuropeptides in rat brain

    Författare :Susanne H M Gruber; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Schizophrenia; D-amphetamine; Antipsychotic drugs; Neurotensin; Neuropeptide Y; Rat brain; Microdialysis;

    Sammanfattning : Schizophrenic patients have been reported to have lower concentrations of neurotensin (NT)-like immunoreactivity (-LI) in their cerebrospinal fluid (CSF) that normalize after treatment with antipsychotic drugs. Schizophrenic patients also had higher CSF concentrations of neuropeptide Y (NPY)-LI compared to controls, thus involvement of NPY in the disease has also been suggested. LÄS MER

  3. 2. The kynurenine pathway and development of schizophrenia : immunological and genetic aspects

    Författare :Maria Holtze; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Schizophrenia is a complex disorder with symptoms ranging from hallucinations to poor social functioning and cognitive deficits. Despite decades of research, the etiology of the disease remains puzzling. Genetic aberrations as well as exposure to infection during early life are associated with an increased risk for development of the disease. LÄS MER

  4. 3. Drug and disease effects on the human brain studied by functional MRI

    Författare :Love Engström Nordin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: With the advent of magnetic resonance imaging (MRI) technology, various functional MRI (fMRI) techniques have become available for non-invasive neuroscientific studies and clinical diagnostics, which have led to a better understanding of the human brain function in normal and diseased subjects. In order to interpret the fMRI results correctly and design optimal research studies it is important to understand both the potentials and limitations associated with each fMRI technique. LÄS MER

  5. 4. Imbalanced kynurenine pathway in schizophrenia and depression : immunological and genetic aspects

    Författare :Xicong Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Kynurenic acid (KYNA), an end metabolite of the kynurenine pathway along tryptophan degradation, has gained increasing interest in the pathophysiology of psychiatric disorders. Elevated levels of KYNA have been found in the cerebrospinal fluid (CSF) and in the postmortem brain of patients with schizophrenia and bipolar disorder with psychotic symptoms. LÄS MER

  7. 5. Exploring dual-lipopolysaccharide exposure on schizophrenia-like behavior and the kynurenine pathway in rodent models

    Författare :Yiran Zheng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Immune activation contributes to the pathophysiology of schizophrenia. The kynurenine pathway, serving as the primary route of tryptophan catabolism, has been posited as a potential link between immune activation and the manifestation of symptoms associated with schizophrenia. LÄS MER