Sökning: "Calpain inhibitor"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden Calpain inhibitor.

  1. 1. Calpain-Mediated Apoptosis in Motor Neurons of Adult Mouse Spinal Cord Slices

    Författare :HamidReza Momeni; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Calpain; Djurfysiologi; Animal physiology; Spinal cord; Organ culture; Mouse; Motor neurons; Caspase; Calpain inhibitor; Calpain activity; Apoptosis;

    Sammanfattning : Motor neuron degeneration is a critical phenomenon during spinal cord injuries and some neurodegenerative diseases. However, the mechanisms by which cell death is induced in these neurons are poorly understood. LÄS MER

  3. 2. Aspects of pathological apoptosis in the immature brain after hypoxia-ischemia

    Författare :Ulrika Hallin; Göteborgs universitet; []
    Nyckelord :neonatal; rat; brain; hypoxia-ischemia; necrosis; apoptosis; calpain; caspase; Bcl-2; Bax; mitochondria; calcineurin.;

    Sammanfattning : The cause of mechanisms underlying perinatal brain injury is not fully known, but it results in a wide variety of neurological impairments in the affected children. When injured, neurons of the newborn brain are prone to undergo programmed cell death, apoptosis, since this genetic program is normally activated in some cells during development of the nervous system, even in the perinatal period. LÄS MER

  4. 3. Elucidation of pro-apoptotic signaling induced by cisplatin

    Författare :Aleksandra Mandic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Keywords: Cisplatin; apoptosis; signal transduction; Bak; calpain; endoplasmic reticulum;

    Sammanfattning : A major clinical problem regarding treatment of malignant tumors with anticancer drugs is inherent or acquired resistance to therapy. One factor contributing to drug resistance of cancer cells is failure to undergo apoptosis. LÄS MER

  5. 4. Analysis and manipulation of autoreactive and tumor-specific T cell responses

    Författare :Jelena Petrovic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Autoimmune Diabetes Mellitus; T cell immune response; proteasome inhibitor;

    Sammanfattning : The focus of this work has been on the analysis and manipulation of T cell responses. One emphasis has been on T cells involved in autoimmune diabetes and another on T cells in tumor immunity. Primary activation of T cells as well as the role of the proteasome in T cell responses has been overlapping themes. LÄS MER

  7. 5. The role of the MAP- and SAP- kinase pathways in the survival, proliferation and death of Schwann cells of the injured sciatic nerve

    Författare :Lisa Mårtensson; Funktionell zoologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : This thesis concerns alterations in signal transduction in Schwann cells as a response to nerve injury as well as their survival, proliferation and death. Enzymes and transcription factors belonging to the mitogen activated protein kinase (MAPK) and the stress activated protein kinase (SAPK) pathways were studied. LÄS MER