Sökning: "Budding yeast"

Visar resultat 21 - 25 av 49 avhandlingar innehållade orden Budding yeast.

  1. 21. Fission yeast mediator complex and its role in transcriptional regulation

    Författare :Olga Khorosjutina; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mediator is an evolutionary conserved co-activator complex that regulates transcription of protein encoding genes in eukaryotes. This multiprotein complex was first identified in budding yeast and shown to be indispensable for RNA polymerase II (pol II) dependent transcription. LÄS MER

  3. 22. On the role of actin in yeast protein quality control

    Författare :Lisa Larsson Berglund; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein quality control; Actin; Protein aggregate; Segregation; Polarisome; CCT; Huntingtin;

    Sammanfattning : Every cell is equipped with a protein quality control system to ensure the proper function of proteins. This is essential for both cell maintenance and the generation of new and healthy cells. LÄS MER

  4. 23. The construction, analysis and validation of mechanistic mathematical models of protein kinetics in the context of replicative ageing in budding yeast

    Författare :Johannes Borgqvist; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein kinetics; Replicative ageing; Cdc42; Ordinary differential equations; Reaction diffusion models; Parameter estimation; Model validation; Model construction; Symmetry methods;

    Sammanfattning : Mathematical modelling constitutes a forceful tool for elucidating properties of biological systems. Using theoretical approaches in combination with experimental techniques it is possible to study specific molecular aspects of phenomena such as the ageing of human beings. LÄS MER

  5. 24. Metabolic regulation and anticancer drug resistance in the yeast Saccharomyces cerevisiae

    Författare :Mattias Carlsson; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Cancer is a malignant neoplastic tissue. The pyrimidine analogue 5-fluorouracil is an anticancer drug used against several types of cancer. It owes its specificity against neoplasms due to the higher rate of nutrient uptake, RNA and DNA synthesis, and in particular the higher rate of nucleobase scavenging and salvage of neoplastic cells. LÄS MER

  7. 25. Studies of cohesin functions in the yeast and human DNA damage response

    Författare :Elin Enervald; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Maintaining genome stability is critical to cell survival and normal cell growth and most human cancers display some form of genome instability. Genome instability is caused by multiple reasons and the ability to properly recognize, signal and subsequently repair DNA damages is crucial. LÄS MER