Sökning: "Antiviral Agents"
Visar resultat 16 - 20 av 25 avhandlingar innehållade orden Antiviral Agents.
16. Studies on the antiproliferative action of interferon : effects on proteins synthesized in the G1 and S phase of the cell cycle in 2 anchorage-dependent cell lines
Sammanfattning : Interferons (IFNs) are a class of structurally related proteins first discovered to be produced by virus-infected cells. By now, several other inducing agents have been described. LÄS MER
17. Reverse genetic studies of Enterovirus replication
Sammanfattning : Enteroviruses belong to the Picornaviridae family and are small icosahedral viruses with RNA genomes of positive polarity, containing a single open reading frame. They mostly cause mild or asymptomatic infections, but also a wide array of diseases including: poliomyelitis, encephalitis, gastroenteritis, aseptic meningitis, myocarditis, hand-foot-and-mouth disease, hepatitis and respiratory diseases, ranging from severe infections to the common cold. LÄS MER
18. HIV-1 reverse transcriptase as a target in the development of specific enzyme inhibitors
Sammanfattning : Human immunodeficiency virus type I (HIV-I), which causes the acquired immunodeficiency syndrome (AIDS), begins its intracellular infection life cycle with reverse transcription of its plus-strand RNA genome into a double-stranded proviral DNA intermediate which is integrated into the host chromosome inducing a persistent infection. A virally encoded enzyme, reverse transcriptase (RT), carries out the reverse transcription process by performing all three enzymatic activities, i. LÄS MER
19. Deoxyribonucleoside kinases in nuclear and mitochondrial DNA precursor synthesis : phosphorylation of anti-cancer nucleoside analogs in different subcellular compartments
Sammanfattning : Nucleoside analogs have been developed as anticancer and antiviral agents. The main mechanism of action of nucleoside analogs is the incorporation of the corresponding analog triphosphate into DNA where it interferes with DNA replication. LÄS MER
20. Human dendritic cells in blood and airways during respiratory viral infection
Sammanfattning : The air we inhale contains oxygen necessary for life, but also potentially harmful microorganisms, toxins and allergens. This presents an important immunological dilemma: how can our lungs quickly and selectively eliminate harmful agents without inflicting damage on the delicate tissues of the lungs? We have thus evolved a network of cells involved in immune surveillance, made up of dendritic cells (DCs), monocytes and macrophages. LÄS MER
