Sökning: "Akhtar ali"

Hittade 2 avhandlingar innehållade orden Akhtar ali.

1. 1. Understanding Cancer Mutations by Genome Editing

   Författare :Muhammad Akhtar Ali; Tobias Associate Professor; Thierry Soussi; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genome editing; rAAV; ZBED6; DIP2C; KRAS; BRAF; colorectal cancer; tumor driver genes; cancer pathways;

   Sammanfattning : Mutational analyses of cancer genomes have identified novel candidate cancer genes with hitherto unknown function in cancer. To enable phenotyping of mutations in such genes, we have developed a scalable technology for gene knock-in and knock-out in human somatic cells based on recombination-mediated construct generation and a computational tool to design gene targeting constructs. LÄS MER

3. 2. Refractory High Entropy Alloys and Films for High Temperature Applications

   Författare :Sajid Ali Alvi; Farid Akhtar; Marta-Lena Antti; Ulf Jansson; Luleå tekniska universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Engineering Materials; Materialteknik;

   Sammanfattning : High-entropy alloy (HEA) is a multi-component alloy constituting five or more principal elements in equi- or near equi-atomic percentages. The high configurational entropy in a HEA composition, in contrast to conventional alloys, leads to the stabilisation of the alloying elements in stable solid solutions of face-centred-cubic (FCC), body-centred-cubic (BCC) and/or amorphous structures. LÄS MER